孕晚期孕妇血清β-hCG与早发型重度子痫前期关系研究

Study on the relationship between serum β-hCG and early onset severe preeclampsia among the pregnant women during the third trimester of pregnancy

目的:探讨孕晚期孕妇血清β-hCG水平变化与早发型重度子痫前期的关系及其临床意义。方法:选择诊治的妊娠期高血压孕妇159例为研究对象,以同期正常孕妇为对照组,采用酶联免疫吸附法检测血清β-hCG,比较两组患者之间的差异。结果:实验组1血清β-hCG水平与对照组无明显差异(P>0.05),实验组2和实验组3血清β-hCG水平显著高于对照组(P<0.05)。正常妊娠组与妊娠期高血压疾病组患者血清β-hCG水平从妊娠28周起至34周均呈逐渐上升的趋势,而早发型重度子痫前期血清β-hCG水平在各个孕周均明显高于正常妊娠者(P<0.05),在33～34周达到最高,最高时较正常妊娠组孕妇高37.84 ng/ml。结论:妊娠晚期孕妇血清β-hCG水平可作为早发型重度子痫前期患者胎盘功能及病情发展的评价指标,应积极进行监测。

Objective： To explore the relationship between the change of serum β - human chorionic gonadotropin （ β - hCG） level and early onset severe preeelampsia, analyze its clinical significance. Methods ： One hundred and fifty - nine pregnant women with hyperten- sive disorder complicating pregnancy （HDCP） who were diagnosed and cured in the hospital were selected as study objects, and normal preg- nant women during the same period were selected as control group. ELISA was used to compare the differences of the patients in the two groups, Results ： There was no statistically significant difference in the serum level of β - hCG between experimental one group and control group （ P 〉 0. 05 ） ; the serum levels of β - hCG in experimental two group and experimental three group were significantly higher than that in control group （P 〈 0.05 ） . From 28th gestational week to 34th gestational week, the serum levels of β -hCG in normal pregnancy group and HDCP group showed gradual increasing trends, but the serum levels of β - hCG in early onset severe preeclampsia group at different ges- rational weeks were significantly higher than those in normal pregnancy group （ P 〈 0. 05 ） , which peaked at 33 - 34 gestational weeks, and the peak levels were higher than those in normal pregnancy group by 37.84 ng/ml. Conclusion： Serum β - hCG level can be used as an e- valuation index for placental function and disease development of the patients with early onset severe preeclampsia, so it should be monitored actively.