重度子痫前期患者生化指标与胎盘早剥的关系研究

Study on the relationship between biochemical indexes and placental abruption of the patients with severe preeclampsia

目的:通过比较重度子痫前期诱发的胎盘早剥孕妇血清中CAl25及AFP水平探讨其对胎盘早剥早期诊断的临床应用价值。方法:选取72例重度子痫前期孕妇作为研究对象,其中45例患者伴有胎盘早剥,采用微粒酶免疫分析法检测孕妇血清中CAl25、AFP水平,并对结果进行比较分析。结果:重度子痫前期合并胎盘早剥组CAl25和AFP为(231.4±53.1)U/ml和(357.2±78.5)mg/ml比单纯重度子痫前期组(117.6±76.3)U/ml和(273.4±82.9)mg/ml明显升高,差异有统计学意义(P<0.01)。结论:血清中CAl25及AFP等生化参数可以作为胎盘早剥的预测及早期诊断的实验室检查指标,具体数值标准仍需进一步论证。

Objective： To explore the clinical values of serum cancer antigen 125 （CA125） and alpha- fetoprotein （AFP） for early diagnosis of placental abruption by comparing the serum levels of CA125 and AFP between the pregnant women with severe preeclamp- sia and the pregnant women with severe preeclampsia - induced placental abruption. Methods： Seventy - two pregnant women with severe preeclampsia were selected as study objects, including 45 patients with severe preeclampsia- induced placental abruption; micropartical en- zyme immunoassay was used to detect the serum levels of CA125 and AFP, then the results were compared and analyzed. Results： The ser- um levels of CA125 and AFP in severe preeclampsia - induced placental abruption group were （ 231.4±53.1 ） U/ml and （ 357.2± 78.5 ） mg/ml, respectively, which were significantly higher than those in simple severe preeclampsia group [ （ 117.6±76. 3 ） U/ml and （273.4 ± 82.9） mg/ml, respectively ], there was statistically significant difference （ P 〈 0. 01 ） . Conclusion ： The biochemical parame- ters, such as serum CA125 and AFP, can be used as experimental indexes to predict and diagnose placental ahruption early, the standards of specific values still need further argumentations.