培菲康口服和灌肠疗法治疗新生儿黄疸的研究分析

Study and analysis on oral administration of bifid triple viable and enema therapy in treatment of neonatal jaundice

目的:探讨培菲康联合灌肠疗法治疗新生儿黄疸的临床疗效。方法:102例正常足月病理性黄疸新生儿随机分为对照组和治疗组,每组51例。两组均行常规治疗,治疗组在常规治疗方法的基础上加用口服培菲康0.5 g口服和生理盐水5～10 ml(39～41℃)灌肠,每日均3次。观察2组治疗1～4天前后新生儿经皮胆红素浓度指数变化。结果:治疗组的总有效率为94.12%,明显高于对照组的84.31%(P<0.05);与治疗前比较,2组治疗后胆红素浓度均显著下降(P值均<0.05),且治疗组下降更明显(P<0.05)。结论:培菲康联合灌肠疗法治疗新生儿黄疸疗效确切显著,值得推广。

Objective： To explore the clinical curative effect of bifid triple viable combined with enema therapy in treatment of neo- natal jaundice. Methods： One hundred and two normal full - term neonates with pathological jaundice were randomly divided into control group and treatment group, 51 neonates in each group, The neonates in the two groups were treated with routine therapy, while on the basis of routine therapy, the neonates in treatment group were treated with oral administration of bifid triple viable （0. 5 g） and enema therapy with normal saline （5 - 10 ml, 39℃ -41 ℃ ） , three times a day. The changes of transdermal bilirubin concentration before treatment and at 1 - 4 days after treatment in the two groups were observed. Results： The total effective rate of treatment group was 94. 12%, which was signifi- cantly higher than that of control group （84. 31% ） （P 〈 0. 05 ） . After treatment, the bilirubin concentrations in the two groups after treat- ment decreased significantly （ P 〈 0. 05 ）, especially in treatment group （ P 〈 0. 05 ） . Conclusion： The curative effect of bifid triple viable combined with enema therapy is good in treatment of neonatal jaundice, and the method is worthy to be popularized.