6例圆头精子症患者临床分析

Clinical analysis on six patients with globozoospermia

目的:探讨圆头精子症患者病因和临床表型特征。方法:收集6例圆头精子症导致不育患者和8例正常生育男性基本信息,进行外周血染色体、AZF、性激素、精液质量检查。结果:6例患者不育年限平均为4年,其中4例从事电焊、汽车喷漆、高温作业、接触化学物品职业,2例从事网络和电子商务;6例患者临床特征、染色体和AZF基因、性激素未见异常,3例患者圆头精子率100.00%,3例圆头精子率95.00%～99.50%,圆头精子症患者精子活力明显低于正常生育组(P<0.05)。结论:圆头精子症发生可能与外界环境有关,除具有圆头精子和精子活力低下外,无其他异常表型,建议采用辅助生殖技术助孕。

Objective： To explore the etiological factors and clinical phenotypic characteristics of the patients with globozoospermia. Methods： The basic data of six patients with globozoospermia induced infertility and eight men with normal infertility were collected, then chromosomal examination, azoospermia factor （AZF） detection, detection of sex hormones in peripheral blood , and examination of semen quality were carried out. Results,： The mean infertile time of six patients was four years, four patients were engaged in electrical welding, ear painting, occupations working at high temperature or touching chemicals; two patients took part in network and electronic commerce. The clinical characteristics, chromosomes and AZF gene, sex hormones of six patients had no abnormality; the incidence of globozoospermia of three patients was 100. 00%, and the incidence of globozoospermia of the other three patients was 95. 00% - 99. 50%, the activity of sperms among the patients with globozoospermia was significantly lower than that in normal fertility group （P 〈 0.05） . Conclusion：The occurrence of globozoospermia may be related to external environment; except globozoospermia and asthenospermia, no other abnormal phenotypes were found ; it is suggested to adopt assisted reproductive techniques.