摘要
AIM: To investigate the intratumoral expression of metastasis-associated in colon cancer 1 (MACC1) and c-Met and determine their clinical values associated with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). METHODS: A retrospective study admitted three hundred fifty-four patients with HBV-related HCC. The expression and distribution of MACC1 and c-Met were assessed by quantitative real-time polymerase chain reaction and immunohistochemistry staining. Prognostic factors influencing survival, metastasis and recurrence were assessed. RESULTS: Intratumoral MACC1 level was found to be associated with HCC disease progression. Both median tumor-free survival (TFS) and overall survival (OS) were significantly shorter in the postoperative HCC patients with high intratumoral MACC1 expression, as compared to those with low intratumoral MACC1 levels (TFS: 34 mo vs 48.0 mo, P < 0.001; OS: 40 mo vs 48 mo, P < 0.01). Multivariable analysis indicated that high MACC1 expression or co-expression with c-Met were independent predictors for HCC clinic outcome (P < 0.001). CONCLUSION: High intratumoral MACC1 expression can be associated with enhanced tumor progression and poor outcome of HBV-related HCC. MACC1 may serve as a prognostic biomarker for postoperative HCC.
AIM： To investigate the intratumoral expression of metastasis-associated in colon cancer 1 （MACC1） and c-Met and determine their clinical values associated with hepatitis B virus （HBV）-related hepatocellular carcinoma （HCC）. METHODS： A retrospective study admitted three hundred fifty-four patients with HBV-related HCC. The expression and distribution of MACC1 and c-Met were assessed by quantitative real-time polymerase chain reaction and immunohistochemistry staining. Prognostic factors influencing survival, metastasis and recurrence were assessed. RESULTS： Intratumoral MACC1 level was found to be associated with HCC disease progression. Both median tumor-free survival （TFS） and overall survival （OS） were significantly shorter in the postoperative HCC patients with high intratumoral MACC1 expression, as compared to those with low intratumoral MACC1 levels （TFS： 34 mo vs 48.0 mo, P 〈 0.001; OS： 40 mo vs 48 mo, P 〈 0.01）. Multivariable analysis indicated that high MACC1 expression or co-expression with c-Met were independent predictors for HCC clinic outcome （P 〈 0.001）. CONCLUSION： High intratumoral MACC1 expression can be associated with enhanced tumor progression and poor outcome of HBV-related HCC. MACC1 may serve as a prognostic biomarker for postoperative HCC.
基金
Supported by Grants from the Key Scientific and Technological Research Foundation of the National Special-purpose Program,No. 2008ZX10002-018
from the Capital Medical Development and Research in Beijing, China, No. 2007-1021 and2009-2041
关键词
肝炎病毒
预测因子
结肠癌
肝癌
预后
B型
移相
免疫组织化学染色
Hepatocellular carcinoma
Metastasis-as-sociated in colon cancer 1
c-Met
Prognostic factor
Recurrence
