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Wnt/β-catenin-TCF信号通路介导溃疡性结肠炎相关癌变分子机制研究 被引量：7

Wnt/β-catenin-TCF Signal Pathway Mutation in Ulcerative Colitis-related Carcinogenesis
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摘要 溃疡性结肠炎相关癌变机制尚未明确,可能与炎症反复发作以及炎症细胞产生多种细胞因子、活性氧等因素,激活经典的Wnt/β-catenin-TCF通路突变,出现结肠黏膜上皮细胞反复坏死、再生、增殖,甚至癌变。该文主要探讨Wnt/β-catenin通路介导溃结癌变相关机制研究进展。 The mechanism in ulcerative colitis - related carcinogenesis is unknown. It was reported that the mechanism in UCAC maybe related with several cytokine or active oxygen which induced by inflammation. Meanwhile, the Wnt/β- catenin - TCF signal pathway mutation plays an important role in UCAC. The development about the mechanism of UCAC was discussed in this article.
作者 张涛 梁建英 黄会云 陈远能 黄适 王小平
机构地区 广西中医学院附属瑞康医院 广西壮族自治区柳城县人民医院 江西中医药高等专科学校
出处 《时珍国医国药》 CAS CSCD 北大核心 2012年第6期1536-1537,共2页 Lishizhen Medicine and Materia Medica Research
基金 国家自然科学基金面上项目(No.81001507) 广西壮族自治区卫生厅重点项目(No.2011041) 广西中西医学院附属瑞康医院重点资助项目(No.RKZ201006)
关键词 Wnt/β-catenin-TCF通路 溃疡性结肠炎 癌变 Wnt/β - catenin - TCF pathway Ulcerative colitis Carcinogenesis
分类号 R284.2 [医药卫生—中药学]
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参考文献22

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二级参考文献4

共引文献265

同被引文献79

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引证文献7

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时珍国医国药
2012年 第6期

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