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丹参酮ⅡA对房颤大鼠外周血肿瘤坏死因子α表达的影响 被引量：3

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摘要 目的通过探讨丹参酮ⅡA(TanⅡA)对房颤(AF)大鼠外周血肿瘤坏死因子α(TNF-α)表达的影响,揭示活血祛瘀中药预防和治疗房颤的作用机制。方法采用乙酰胆碱-氯化钙(Ach-Cacl2)药物经尾静脉注射法复制AF大鼠模型,随机分成3组:模型组、丹参酮ⅡA组、维拉帕米干预组。并另设正常对照组。用药两周后,观察丹参酮ⅡA对房颤大鼠外周血TNF-α表达的影响。结果与正常对照组相比,模型组的TNF-α水平明显增高(P<0.01);与模型组相比,丹参酮ⅡA组及维拉帕米干预组的TNF-α水平降低(P<0.01),丹参酮ⅡA组降低更明显。结论丹参酮ⅡA能够明显降低血清TNF-α的水平,可能通过抑制炎症因子的表达,改善房颤心房组织损伤,从而治疗房颤。
作者 刘维琴 马清华
机构地区 贵阳中医学院第二附属医院 贵阳中医学院
出处 《时珍国医国药》 CAS CSCD 北大核心 2012年第6期1573-1574,共2页 Lishizhen Medicine and Materia Medica Research
关键词 丹参酮ⅡA 肿瘤坏死因子Α 房颤
分类号 R962 [医药卫生—药理学]
  • 相关文献

参考文献12

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二级参考文献16

  • 1徐长庆,王孝铭,范劲松,郝雪梅,周盈颖,刘泰.丹参酮Ⅱ-A对豚鼠单个心室肌细胞跨膜电位及L-型钙电流的影响[J].中国病理生理杂志,1997,13(1):43-47. 被引量：74
  • 2Boixel C, Fontaine V, Rucker-Martin C, et al. Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat[J]. J Am Coll Cardiol, 2003, 42:336
  • 3Engel D, Peshock R, Robert C, et al. Cardiac myocyte apoptosis provokes adverse cardiac remodeling in transgenic mice with targeted TNF overexpression [ J ]. AJP-Heart,2004, 287 : 1 303
  • 4Yokoyama T, Nakano M, Bednarczyk JL, et al. Tumor necrosis factor-αprovokes a hypertrophic growth response in adult cardiac myocytes[J]. Circulation , 1997,95:1 247
  • 5Sun M, Dawood F, Hu WW, et al. Excessive tumor necrosis factor activation after infarction contributes to susceptibility of myocardial rupture and left ventricular dysfunction[J]. Circulation, 2004,110:3 221
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共引文献121

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二级引证文献27

时珍国医国药
2012年 第6期

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