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胃癌组织中Cyr 61、VEGF表达的意义

Expression Significances of Cyr 61 and VEGF in Gastric Carcinoma
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摘要 目的研究胃癌组织中Cyr 61和VEGF的表达与临床病理学特征的关系。方法应用免疫组织化学方法检测70例胃癌组织以及20例胃癌癌旁组织中Cyr 61和VEGF的表达。结果 Cyr 61和VEGF的在胃癌组织中表达均显著高于癌旁组织(P<0.05);胃癌组织中Cyr 61和VEGF表达与浸润深度、淋巴结转移、TNM分期密切相关(P<0.05);Cyr 61和VEGF表达呈正相关性(P<0.05)。结论 Cyr 61和VEGF在胃癌组织中高表达,两者在胃癌的生成和进展中起重要作用。 Objective To investigate the expression of Cyr 61, VEGF and their relationship with clinicopathologic characteristics in gastric carcinoma. Methods The expressions of Cyr 61 and VEGF in 70 cases of gastric carcinoma, 20 eases of adjacent normal tissue were evaluated by immunohistochemis- try. Results The expressions of Cyr 61 and VEGF were significantly higher in gastric carcinoma than in adjacent normal colonic tissues（P 〈0.05） . Cyr 61 and VEGF expressions were correlated with the de- gree of infiltration depth, lymph node metastasis and TNM stage （P 〈 0.05 ）. A significant correlation was found between Cyr 61 and VEGF expressions（P 〈 0.05 ）. Conclusion There are high expressions of Cyr 61 and VEGF in gastric carcinoma, which indicate that Cyr 61 and VEGF play an important role in pro- moting tumor angiogenesis and progression of gastric carcinoma.
作者 史飞涛 秦守杰 孔武明
机构地区 焦作市人民医院消化内科
出处 《河南职工医学院学报》 2012年第3期272-274,共3页 Journal of Henan Medical College For Staff and Workers
关键词 胃癌 Cyr 61 VEGF 免疫组织化学方法 gastric carcinoma Cyr 61 VEGF immunohistochemical staining
分类号 R735.2 [医药卫生—肿瘤]
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参考文献11

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河南职工医学院学报
2012年 第3期

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