鹊肾树心材的化学成分及体外抗菌活性研究

Constituents from Heartwood of Streblus asper and Their Antibacterial Activity

本文研究鹊肾树Streblus asper心材的乙酸乙酯部分化学成分及体外抗菌活性。运用正相硅胶柱色谱层析,反相C-18柱色谱层析和Sephadex LH-20分离、纯化,最终得到8个化合物,经波谱解析并结合理化鉴定确定化合物结构为:银杏双黄酮(1)、异黄酮-4'-甲氧基-7-α-L-鼠李糖-(1→6)-β-D-葡萄糖(2)、鼠李柠檬素-3-O-β-D-半乳糖苷(3)、β-香树脂酮(4)、β-谷甾醇(5)、香草酸(6)、山俞酸(7)、二十六烷酸(8)。除化合物5外,均为首次从该植物中提取到。此外研究了化合物1-4的抗菌活性,实验表明化合物2具有一定的抑菌活性。

Eight known compounds were isolated by various chromatographic techniques from the heartwood of Streblus asper and their structures were elucidated on the basis of spectroscopic analysis,they are ginkgetin（1）,4′-methoxy-7-α-L-rhamnosyl-（1→6）-β-D-glucopyranosy isoflavone（2）,rhamnocitrin-3-O-β-D-galactopyranoside（3）,β-amyrone（4）,β-sitosterol（5）,vanillic acid（6）,behenic acid（7）,and docosenoic acid（8）.All compounds were isolated from this plant for the first time except for 5.In the antibacterial activities assay,compound 2 showed antibacterial activities.