珂立苏配合气管插管治疗早产新生儿呼吸窘迫的效果观察

目的评价肺表面活性物质珂立苏配合气管插管治疗早产新生儿呼吸窘迫(NRDS)的临床疗效。方法将就诊的137例NRDS患儿随机分为两组,其中珂立苏配合气管插管治疗组,68例,为观察组;另69例NRDS患儿给予无珂立苏常规治疗,为对照组。以SpO2、自主呼吸明显改善及血气变化(PaCO2、PaO2、pH)为观察指标,评价珂立苏配合气管插管治疗早产新生儿呼吸窘迫的临床疗效。结果珂立苏配合气管插管治疗早产新生儿呼吸窘迫,SpO2立即上升至96.4%,自主呼吸明显改善成功率达94.3%,其血气变化(PaCO2、PaO2、pH)与治疗前及对照组治疗后相比差异有统计学意义(P<0.01)。结论应用珂立苏配合气管插管治疗NRDS疗效好,患儿存活率高。

Objective To evaluate the clinical effect of preterm neonatal respiratory distress syndrome treated with calsurf and tracheal intubation.Methods 137 patients with respiratory distress syndrome in our hospital were divided into two groups randomly.68 patients included in the observation group were treated with calsurf and tracheal intubation and the other 69 patients in the control group without calsurf.Results In the observation group,the SpO2 value（96.4%）and the rate of successful（94.3%）were much higher than the control group.The PaCO2,PaO2 and pH of neonates in the two groups were all improved significantly by comparing before and after treatment（P〈0.01）.There was significant difference between the two groups after treatment（P〈0.01）.Conclusion Preterm neonatal respiratory distress syndrome treated with calsurf and tracheal intubation is effective.The rate of surviving is improved.It’s safe to use calsurf for preterm neonatal respiratory distress syndrome.