促性腺激素释放激素类似物治疗女童特发性中枢性性早熟的疗效分析

Effects of gonadotropin releasing hormone analogues on idiopathic central precocious puberty in girls

目的比较分析促性腺激素释放激素类似物(GnRHa)治疗女童特发性中枢性性早熟(ICPP)的临床疗效。方法 51例女童ICPP患儿用GnRHa治疗,疗程1～2年,观察治疗前后促黄体生成素峰值(P-LH)、促卵泡刺激素峰值(P-FSH)、雌二醇(E2)、子宫容积、卵巢容积以及随疗程变化体重指数(BMI)、骨龄(BA)、骨龄与生活年龄比值(BA/CA)、生长速率(GV)、预测成人身高(PAH)的动态变化。结果治疗前后促黄体生成素峰值、促卵泡刺激素峰值比较,差异有统计学意义(P<0.01);治疗前后骨龄与生活年龄比值、生长速率比较,差异有统计学意义(P<0.05);治疗前后预测成人身高有提高趋势,差异有统计学意义(P<0.05)。结论 GnRHa能有效抑制下丘脑-垂体-性腺轴治疗ICPP,但其促身高增长作用有待进一步研究。

Objective To explore the clinical efficacy of gonadotropin releasing hormone analogues（GnRHa） on idiopathic central precocious puberty（ICPP） in girls.Methods Total 51 girls with ICPP were selected,and GnRHa was given to them for 1-2years.Peak of LH and FSH、estradiol、uterus and ovary volume were observed before and after treatment.And body mass index、bone age、bone age/age、growth velocity、predicted adult height were compare on variable treatment.Results The Peak of LH and FSH were significant lower than those before treatment（P〈0.01）;bone age/age、growth velocity were significant lower than those before treatment（P〈0.05）;predicted adult height was higher than that before treatment,and there was significant difference（P〈0.05）.Conclusion GnRHa could inhibit hypothalamus-hypophysis-gonadal axis to cure ICPP,but there are still unresolved questions about the effects on the actual final adult heigh that future studies will need to address.