肺炎支原体感染与儿童哮喘的相关性研究

Dependency between pneumonia MP infection and children bronchial asthma

目的探讨儿童支气管哮喘与肺炎支原体(MP)感染的关系,为儿童哮喘急性发作期的治疗提供依据。方法 50例支气管哮喘急性发作期患儿为观察组,50例上呼吸道感染患儿为对照组,检测两组患儿外周血支原体抗体(MP-IgM),比较两组MP-IgM阳性率;比较观察组MP-IgM阳性患儿与MP-IgM阴性患儿的外周血嗜酸性粒细胞计数(EOS)。MP-IgM阳性组常规给予抗生素、激素及支气管扩张剂治疗基础上加阿奇霉素治疗。结果观察组阳性率42%(21例)显著高于对照组16%(8例),差异有统计学意义(P<0.01);MP-IgM阳性患儿的EOS显著高于MP-IgM阴性患儿,差异有统计学意义(P<0.01)。结论 MP感染与儿童哮喘关系密切,对哮喘发作期患儿要考虑MP感染,应常规行支原体检查,阿奇霉素疗效确切。

Objective To explore the relationship between children bronchial asthma and pneumonia MP infection,in order to provide the data for the treatment of children bronchial asthma at the acute stage.Methods Take 50 cases of brachycranic bronchial asthma and 50 comparative cases of upper respiratory tract infection,Mycoplasma-IgM in peripheral blood was detected,and the positive rats of MP-IgM were compared between the two groups.The children in asthma group were divided into two groups,one group were determined as MP-IgM positive,and the other group were determined as MP-IgM negagtive.The count of eosinophil in peripheral blood were compared between the two groups.Group of conventional therapy is not only treated with antibiotic,hormone and bronchodilators,but also with additional azithromycin.Results Asthma group has 21 positive cases,42% positive;comparative group has 8 positives cases,16% positive,difference is obvious（P〈0.01）;EOS counts in the patiants positive by the MP-IgM test at the acute stage were higher than that negative by the MP-IgM test.the difference was obvious（P〈0.01）.Conclusion MP infection is closely related with children asthma,MP infection shall be considered for stage of attack of asthma.Pneumonia MP inspect shall be carried out.Effectiveness of macrolides antibiotic treatment is assured.