Bmi-1蛋白在食管鳞状细胞癌中表达及临床意义

Expression and Clinical Significance of Bmi-1 Protein in Esophageal Squamous Cell Carcinoma

目的:观察Bmi-1蛋白在食管鳞状细胞癌组织中的表达,探讨Bmi-1与食管鳞状细胞癌的相关性。方法:应用免疫组织化学法检测南京医科大学附属淮安第一医院2005年1月至2006年2月间168例食管鳞状细胞癌组织和30例正常食管黏膜组织Bmi-1蛋白的表达。结果:食管鳞状细胞癌组织和正常食管黏膜组织中Bmi-1蛋白的阳性表达率分别为66.1%(111/168)、23.3%(7/30),Bmi-1蛋白阳性表达率在食管鳞状细胞癌组织和正常食管黏膜组织中差异具有统计学意义(P<0.001),Bmi-1蛋白表达与食管鳞状细胞癌组织学分级、TNM分期和淋巴结转移具有相关性(P=0.016,P=0.004,P<0.001),Bmi-1阴性组的5年生存率显著优于Bmi-1阳性组(P<0.001)。结论:Bmi-1表达异常在食管鳞状细胞癌发生发展中具有重要作用,检测Emi-1的表达对判断食管鳞状细胞癌的预后具有重要意义。

To observe the expression and clinical significance of Bmi-l protein in esophageal squamous cell carcinoma （ ESCC ） and to discuss the correlation between the Bmi-l expression and ESCC. Methods： The expression of Bmi-l protein in 168 cases with the ESCC tissue and 30 with normal esophageal mucosa was determined through immunohistochemistry. Results： The expression rates of Bmi-l were 66.1% （ 111/168 ） and 23.3% （ 7/30 ） in the ESCC tissues and normal esophageal mucosa, respectively. Statistically significant differences were observed in the positive expression of Bmi-l between the ESCC and the normal mucosal tissues of the esophagus （ P 〈 0.001 ）. The positive expression of Bmi-l in ESCC has been found to be related to the histological differentiation, TNM stages, and lymphatic metastases （ P = 0.016, P = 0.004, and P = 0.001 ）. Moreover, the 5-year survival was superior in the Bmi-l-negative group than that in the Bmi-l-positive group （ P 〈 0.001 ）. Conclusion： Bmi-l may play an important role in oncogenesis and progression of ESCC. Detection of the Bmi-l expression is important in evaluating the prognosis of ESCC.