胰高血糖素样肽-1及其类似物对心血管系统的影响

Effects of glucagon-like peptide-1 and analogues on cardiovascular system

心血管病变是糖尿病常见的并发症,胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)作为一种肠促胰素,不仅具有葡萄糖浓度依赖性降糖作用、促进胰腺β细胞增生和修复、改善胰岛素抵抗,而且还可减轻体质量、调节脂质代谢、改善心血管危险因素。研究表明GLP-1可直接作用于血管内皮细胞和心肌细胞,对心血管系统可能具有保护效应。

Cardiovascular diseases are common complications of diabetes. As an incretin hormone, glucagon-like peptide- 1（GLP-1） has the ability of lowering blood, increasing beta cells proliferation and reparation, and ameliorating insulin resistance. Presumably in consequence to these primary actions, it reduces body weight, regulates lipid metabolism, and reduces the risk of cardiovascular diseases. Research indicates that GLP-1 has direct effect on vascular endotheliocyte and myocardial cells and shows possible cardiovascular protective effect.