1,6-二磷酸果糖、参麦注射液联合治疗小儿病毒性心肌炎近期疗效观察

Evaluation of the recent effect of fructose-1,6-diphosphate in combination with Shen-mai injection in the treatment of viral myocarditis in children.

目的 探讨小儿病毒性心肌炎新的治疗方案。方法 115例病毒性心肌炎 ,其中 96例进行了放射性核素心肌显像检查 ,主要采用联合输注 1,6 -二磷酸果糖 (FDP)及参麦治疗 ,观察临床相关症状、体征及心电图 (含 Holter)的转归情况。结果 治疗前后自身对照 ,平均近期有效率分别是 91.6 %和 90 .4% ,缺血性 ST- T变化在 2～ 3周内恢复正常达 10 0 %。结论 联合治疗方案可直接促进磷酸果糖激酶及丙酮酸激酶的活性 ,促进糖酵解 ,产生足够的 ATP而有益于缺血的心肌功能恢复 ,其疗效颇为满意。

Objective To investigate the therapeutic project of viral myocarditis in children.Methods Among 115 viral myocarditis patients,96 cases who underwent radionuclide myocardial imaging examination were treated by combined the rapy of fructose 1,6 diphosphate (FDP) and Shen mai injection.The effect of the treatment through clinical symptoms,signs and ECG (including Holter)were observed.Results Through self case control study before and after treatment,the average efficiency rate was 91 6% and 90 4% respectively.The recovery rate of ischemic ST T change to normal was 100% in 2 to 3 weeks.Conclusion The combined therapeutic project can directly promote the phosphofructokinase and pyruvate kinase′s activity and promote glycolysis,which can produce enough ATP and benefit to the recovery of ischemic myocardium.