十两茶水提物降糖作用及机制研究

Research on the Anti-diabetic Effects of Shi-liang Tea Extract

探讨了湖南安化黑茶的主要品种十两茶水提物的降糖作用及机制.选用6～8周龄db/db自发性糖尿病模型小鼠,每日灌胃给予3个不同剂量的十两茶水提物(100、200、400 mg/kg),连续28 d.每周测定空腹血糖值,实验结束时检测糖耐量和胰岛素水平.研究结果显示,十两茶水提物400 mg/kg给药28 d就能显著降低db/db糖尿病小鼠空腹血糖和改善其对葡萄糖耐受能力.同时,十两茶水提物能显著降低db/db糖尿病小鼠血清胰岛素水平,增加葡萄糖耐量试验胰岛素的释放.结果显示十两茶水提物对2型糖尿病小鼠具有很好的降糖作用,其作用机制与增加胰岛素敏感性有关.

The effect of shi-liang tea extract, a major Anhua deep-black tea, on blood glucose in db/db diabetic mice, was studied. The three different dose of water extract shi-liang tea （100, 200 or 400 mg/kg） were orally treated per day in 6-8 week-old db/db diabetic mice for 28 days. The level of fast blood glucose （FBG） was determined per week in the experiment period, and glucose tolerance and insulin level were determined at the end of the experiment. Treatment with shi-liang tea （400 mg/kg） for 28 days could markedly decrease FBG and insulin level in db/db diabetic mice. This treatment also improved the glucose tolerance and increase insulin release in glucose load experiment in db/db diabetic mice. The water extract of shi-liang tea exert a strong lowering-glucose effect and its effect may be related to increasing sensibility of tissues to insulin.