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蛋白酶活化受体1在不同肿瘤中的研究进展 被引量：1

Progresses on Protease-activated Receptor 1 in Various Tumors
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摘要 人蛋白酶活化受体1(PAR-1)是蛋白酶活化受体家族的成员之一.它活化方式特殊,生物学功能广泛.已经证实PAR-1在黑色素瘤、乳腺癌、胃癌、鼻咽癌、前列腺癌癌旁间质、肝癌、结肠癌等组织中表达上调,在肿瘤细胞的增殖和转移过程中发挥重要作用,可作为患者临床病理分期及预后的标志物. Protease-activated receptor-1 （PAR-l） is a member of protease-activated receptor family. With special activation manner and various functions, PAR-1 has been verified to be up-regulated in melanoma, breast cancer, gastric cancer, nasopharyngeal carcinoma, adjacent stroma of prostate cancer, lung cancer, and colorectal cancer. It plays important roles in tumor proliferation and metastasis, and is regarded as a promising biomarker for clinical pathological staging and prognosis in various malignancies.
作者 张立华 蒋星军 冯湘玲 刘卫东 张树菊 任彩萍
机构地区 中南大学肿瘤研究所 中南大学湘雅医院
出处 《生命科学研究》 CAS CSCD 北大核心 2012年第3期277-282,共6页 Life Science Research
基金 国家973项目资助(2010CB833605) 教育部新世纪优秀人才支持计划资助项目(NCET-10-0790) 中南大学杰出青年培育资助项目(2010QYZD006) 中南大学贵重仪器设备开放共享基金资助项目(CSUZC2012010 CSUZC2012011) 国家自然科学基金资助项目(30801322 81172206) 湖南省自然科学基金资助项目(10JJ4025)
关键词 蛋白酶活化受体1(PAR-1) 上调 转移 预后 protease-activated receptor- 1 （PAR- 1） up-regulation metastasis prognosis
分类号 R73-37 [医药卫生—肿瘤]
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参考文献42

  • 1VU T K, HUNG D T, WHEATON V 1, et aL Molecular cloning of a functional thrombin receptor reveals a novel pro- teolytic mechanism of receptor activation [J]. Cell, 1991, 64(6): 1057-1068.
  • 2KULIOPULOS A, COVIC L, SEELEY S K, et at. Plasmin de- sensitization of the PARI thrombin receptor: kinetics, sites of truncation, and implications for thrombolytic therapy[J]. Bioch- emistry, 1999, 38(14): 4572-4585.
  • 3RIEWALD M, KRAVCHENKO V V, PETROVAN R J, et al. Gene induction by coagulation factor Xa is mediated by acti- vation of protease-activated receptor 1[J]. Blood, 2001, 97(10): 3109-3116.
  • 4RIEWALD M, PETROVAN R J, DONNER A, et al. Activa- tion of endothelial cell protease activated receptor 1 by the protein C pathway[J], Science, 2002, 296(5574): 1880-1882.
  • 5BOIRE A, COVIC L, AGARWAL A, et al. PAR1 is a matrix mctalloprotease-1 receptor that promotes invasion and tumori- genesis of breast cancer cells[J]. Cell, 2005, 120(3): 303-313.
  • 6FANG Q, LIU x, ABE S, et al. Thrombin induces collagen gel contraction partially through PAR! activation and PKC-ep- silon[J]. European Respiratory Journal, 2004, 24(6): 918-924.
  • 7HU H, YAMASHITA S, HUA Y, et al. Thrombin-induced neuronal protection: role of the mitogen activated protein ki- nase/ribosomal protein S6 kinase pathway[J]. Brain Research, 2010, 1361: 93-101.
  • 8MADAMANCHI N R, LI S, PATTERSON C, et al. Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway[J]. Journal of Biologica! Che- mistry, 2001, 276(22): 18915-18924.
  • 9YIN Y J, KATZ V, SALAH Z, et al. Mammary gland tissue targeted overexpression of human protease-activated receptor 1 reveals a novel link to beta-catenin stabilization[J]. Cancer Re- search, 2006, 66(10): 5224-5233.
  • 10TANTIVEJKUL K, LOBERG R D, MAWOCHA S C, et al. PARl-mediated NFkappaB activation promotes survival of prostate cancer cells through a Bel-xL--dependent mechanism[J], Journal of Cellular Biochemistry, 2005, 96(3): 641-652.

二级参考文献56

  • 1孟宇宏,张金强,朱彦君,宁浩勇,胡明,姚林,郑集义,王妍,陆应麟,虞积耀.肺癌中凝血酶受体-1的表达及意义[J].临床与实验病理学杂志,2004,20(3):308-312. 被引量：7
  • 2孟宇宏,虞积耀,陆应麟,朱彦君,张金强,宁浩勇,胡明,刘肖,康筱玲,段玮.凝血酶受体-1在肺癌组织中的表达及其与转移的关系[J].中华病理学杂志,2006,35(1):24-28. 被引量：2
  • 3汤钊猷.肝癌临床研究之我见[J].中华肝脏病杂志,2006,14(7):481-482. 被引量：12
  • 4Tsugane S, Sasazuki S. Diet and t he risk of gastric cancer:review of epidemiological cvidence[J]. Gastric Cancer, 2007, 10:75-83.
  • 5Hamilton SR, Aaltonen LA, Edit. World Health Organization classification of tumours, pathology and genetics of turnouts of digestive system[M]. Lyon, IARC Press, 2000:37-67.
  • 6Depasquale I, Thompson WD. Prognosis in human melanoma: PAR-1 expression is superior to other coagulation components and VEGF[J]. Histopathology, 2008, 52(4) :500-509.
  • 7Tsopanoglou NE, Maragoudakis ME. Role of thrombin in anglogenesis and tumor progression [J]. Semin Thromb Hemost, 2004, 30:63269.
  • 8Beaulieu LM, Church FC. Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR1[J]. Exp Cell Res, 2007, 313(4):677- 687.
  • 9Tellez CS, Davis DW, Prieto VG, et al. Quantitative analysis of melanocytic tissue array reveals inverse correlation between activator protein-2alpha and protease activated receptor 1 expression during melanoma progression[J]. J Invest Dermatol, 2007, 127 (2):387- 393.
  • 10Fujimoto D, Hirono Y, Goi T, et al. Prognostic value of protease-activated receptor-1 (PAR-1) and matrix metalloproteinase-1 (MMP-1) in gastric cancer[J]. Anticancer Res, 2008, 28 (2A) : 847-854.

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生命科学研究
2012年 第3期

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