单纯性肥胖青少年体脂分布与血压及胰岛素抵抗

The relationship of fatty distribution, blood pressure and insulin resistance in adolescent obesity

目的 探讨单纯性肥胖青少年体脂分布与血压及胰岛素抵抗之间的关系。方法 测定了 2 7例单纯性肥胖青少年及 10例非肥胖健康人空腹及口服 75g糖后 1h、2h的血糖及胰岛素浓度 ,计算胰岛素敏感指数 (ISI,RISI) ,比较各指标间的相关性。结果 肥胖患者基础及服 75g糖后 1h、2h胰岛素值均高于对照组 (P <0 .0 0 1) ,胰岛素敏感指数 (ISI,RISI)低于对照组 ,中心型肥胖患者血压高于对照组 (P <0 .0 0 1) ,中心型肥胖组胰岛素敏感指数ISI低于周围型肥胖组。结论 肥胖青少年体内存在着高胰岛素血症 ,胰岛素抵抗及血压偏高的倾向 ,此种情况以中心型肥胖者为著。

Objective To investigate the relationship of fatty distribution, blood pressure and insulin resistance in adolescent obesity.Methods The levels of serum insulin and glucose were measured in fasting state and 1-,2-hour after 75g glucose load in 27 subjects with adolescent obesity and 10 no-obese healthy subjects. Insulin sensitivity index (ISI)and relative insulin sensitivity index (RISI) were calculated.Results The serum insulin levels of fasting state 1-,2-hour after 75g glucose load were significantly greater in the obese adolescents than those in the control ( P <0.001).ISI and RISI in the group of obese adolescents were lower than those in the controls( P <0.001).Comparing with the peripheral obese subjects,the ISI in the central obese group was much lower.Conclusion Obese adolescents are susceptible to hyperinsulinemia, insulin resistance and hypertension,which is much more obvious in central obese subjects. ISI is better than RISI in reflecting insulin sensitivity.