ACE抑制剂培多普利对糖尿病大鼠胸主动脉内皮功能的保护

Protective effect of perindopril on dysfunction of endothelium-dependent relaxation in diabetic rats

探讨血管紧张素转换酶抑制剂培多普利 (perindopril)对糖尿病大鼠血糖浓度、血浆血管紧张素Ⅱ (AngⅡ )及胸主动脉内皮功能的影响。腹腔注射链脲佐菌素 (streptozotocin ,STZ)复制大鼠糖尿病模型 ,分别于 4周、8周、1 6周处死动物 ,取胸主动脉环测定乙酰胆碱 (acetylcholine ,Ach)引起的内皮依赖性舒张反应 ,并测定血糖浓度及血浆AngⅡ浓度。结果发现糖尿病大鼠胸主动脉环Ach 引起的内皮依赖性舒张反应随病程进展呈渐进性下降 ,血浆中AngⅡ浓度升高 ,血糖浓度升高。培多普利可明显改善内皮依赖性舒张反应 ,并降低血浆AngⅡ浓度 。

To investigate the effect of Perindopril, an angiotensin converting enzyme(ACE) inhibitor, on dysfunction of ECs dependent relaxation in diabetic rats induced by streptozotocin(STZ) at different times, acetylcholine(Ach) induced ECs dependent relaxation of rat aortic rings was tested, and the concentrations of plasma glucose and AngⅡ were measured. The results showed that: ①Four weeks later after injecting STZ, the function of ECs dependent relaxation was not injured in diabetic control group(DC), but the concentrations of plasma glucose and AngⅡ were increased significantly compared with normal control group(NC). The Ach induced relaxation was declined obviously compared with NC at 8 or 16 weeks after injecting STZ. ② treatment with Perindopril significantly protected the function of ECs dependent relaxation, the Ach induced relaxation was obviously increased compared with DC. The concentration of plasma glucose was not changed, but the plasma AngⅡ was reduced compared with DC. Conclusion: Perindopril could protect the function of ECs dependent relaxation in diabetic rats. [