铅对大鼠肠道神经元和血管平滑肌细胞NOS活性的影响

Influence of lead on activity of nitric oxide synthase in neurons and vessel smooth muscle of small intestine in rats

用 β NADPH组织化学方法研究铅对大鼠肠壁肌间神经丛内神经元和血管平滑肌一氧化氮合酶 (NOS)活性的影响。结果发现 :腹腔注射醋酸铅 ( 4 0mg·kg- 1 ) 1 5d后 ,大鼠肠道NOS阳性神经元和阳性纤维数量减少 ,且阳性神经元的形态也有不同程度的改变 ,肠壁内血管平滑肌NOS活性下降。

The β NADPH histochemical method was used to study the effect of lead on activity of nitric oxide synthase(NOS) in neurons and vessel smooth muscles of intestinal wall in rats. The results showed that the number of NOS positive neurons and fibers was decreased and degenerative changes of some NOS positive neurons were found after the lead acetate intraperitoneal injection. The activity of NOS in the vessel smooth muscles was reduced. It suggests that lead colic may be induced by reduction of NO in the neurons which innervate the gut smooth muscles. [