前列腺神经内分泌细胞与慢性前列腺炎关系的研究进展

Prostatic neuroendocrine cells and their association with chronic prostatitis

神经内分泌细胞广泛分布于机体神经系统(中枢神经系统和外周神经系统)和神经系统以外的各个器官或组织。正常前列腺组织中除了含有基底细胞和上皮细胞外,同时也存在少量的神经内分泌细胞,对前列腺生长、分泌和分化起着调节作用。近年来研究表明前列腺神经内分泌细胞还可能通过自身的活性及分泌产物参与慢性前列腺炎(CP)的发病机制。本文从前列腺神经内分泌细胞的来源与分布、形态与结构、分泌特性、作用等方面进一步阐述了前列腺神经内分泌细胞及其与CP的关系。

Neuroendocrine cells are abundant in all the body tissues and organs as well as the nervous system, either the central or the peripheral nervous system. In the normal prostate tissue, there are a few neuroendocrine ceils, too, in addition to basal and epithelial cells. Prostatic neuroendocrine cells play the function of regulating the development, secretion and differentiation of the prostate. Recent studies show that prostatic neuroendocrine cells may be involved in the pathogenesis of chronic prostatitis through their activity and secreted products. This article presents an overview on the origin, distribution, morphology, structure, secretion and functions of prostatic neuroendocrine ceUs and their association with chronic prostatitis.