摘要
前列腺癌严重威胁男性健康,早期诊断缺乏特异性生物标志物。caveolin-1(Cav-1)是一种功能基因,也是胞膜窖的重要外壳结构蛋白,与分子运输,细胞粘附和信号转导等多种细胞功能密切相关,在前列腺癌的发生发展中发挥重要作用。Cav-1可作为生物活性分子在前列腺癌微环境中促进肿瘤增殖和肿瘤血管生成。此外,Cav-1在前列腺癌原发灶及转移灶中均过度表达,尤其是转移灶。目前,Cav-1可在外周血被检测到,其表达水平对提高前列腺癌的诊断有提示意义,与预后相关。本文就Cav-1的结构、生物学特性以及与前列腺癌的相关性进行综述。
For lack of the biomarker, early diagnosis of prostate cancer is often difficult. Caveolin-1 （ Cav-1 ） is an important oncogene and a major structural coat protein of caveolae, which is involved in multiple cellular functions including molecular transport, cell adhesion, and signal transduction, as well as in the development and progression of prostate cancer. Cav-1 is secreted as a biologi- cally active molecule that promotes cell survival and angiogenesis within the tumor microenvironment, and is overexpressed in the meta- static and primary sites of human prostate cancer. Secreted Cav-1 can be detected in the peripheral blood, and its expression level has an indicative value in the diagnosis and prognosis of prostate cancer. This review focuses on the structure and biological characteristics of Cav-1 and its correlation with prostate cancer.
出处
《中华男科学杂志》
CAS
CSCD
2012年第7期635-638,共4页
National Journal of Andrology
