中空纤维分子印迹复合膜选择性分离萘普生对映体

Hollow Fiber Imprinted Composite Membranes for Selective Separation of Naproxen Enantiomer

以聚偏氟乙烯(PVDF)中空纤维超滤膜为支撑膜,S-(+)-萘普生为模板分子,4-乙烯基吡啶为功能单体,制备了分子印迹复合膜。通过紫外光谱法研究了模板分子与功能单体之间的相互作用,比较了热聚合和光聚合两种引发方式对膜形貌和性能的影响。试验结果表明,分子印迹聚合物膜中存在着三维空间结构和功能基均与模板分子互补的孔穴组成的通道,该通道可选择性地透过S-(+)-萘普生,在压力和亲和力的协同作用下,最大分离因子可达6.19。

Using polyvinylidene fluoride hollow fiber ultrafiltration membrane as the supported membranes and taking S-（＋）-naproxen as the template, 4-VPy as the functional monomer, the molecularly imprinted composite membrane were prepared. The interaction between template and functional monomer was studied by UV spectrum. The influences on configuration and performance of membranes prepared by thermal and photografting polymerization method were compared. The experiment results show there are paths in the molecularly imprinted membranes formed by the cavities with size and structure accommodated to S-（＋）-naproxen and the maximum separation factor a of the membranes could reach 6.19 at the synergistic effect of pressure and affinity.