内皮素与高血压患者血压水平及左室肥厚的相关性研究

Relationship between the endothelin and blood pressure and left ventricular hypertrophy in essential hypertension

目的 :探讨高血压病 (EH)患者血浆内皮素 (ET)浓度与血压水平及左室肥厚 (LVH)的关系 ;方法 :高血压组 49例 ,正常对照组 2 0例。以特异性放射免疫方法测定血浆ET水平 ,超声心动图诊断LVH ;结果 :EH组血浆ET(90 2 3± 2 2 2 6pg ml)显著高于正常对照组 (66 88± 1 6.0 5 pg ml,P <0 0 1 ) ,轻度EH时ET(83 5 7± 2 2 .2 7pg ml)已有升高 ,中重度 (98 5 4± 2 2 3 4pg ml)高于轻度 (P <0 0 1 ) ,血浆ET与血压水平呈正相关 (r =0 65 7,P <0 0 1 )。EH合并LVH组ET(1 41 0 3± 2 5 78pg ml)较不合并LVH组 (85 1 0± 1 9 91 pg ml)显著增高 (P <0 0 1 ) ,ET值与左室心肌重量指数 (LV MI)呈正相关 (r =0 41 8,P <0 0 1 )。结论 :ET与血压升高关系密切 ,ET对EH的发生及LVH的形成有重要作用。

Objective:To study the relationship between changes of plasma endothelin(ET) and blood pressure and left ventricular hypertrophy(LVH)in patients with essential hypertension(EH);Methods:The plasma ET level were decteded by radioimmunoassay(RIA)method in patients with hypertension(49)and normotensive subjects(20),LVH were determined by echocardiography;Results:The plasma ET level in EH patients was higher than that in normal subjects(90.23±22.26 VS 66.88±16.05pg/ml,P<0 01).ET was in creased in mild hypertensive group(83 57±22 27pg/ml),it was obviously higher in moderate and severe hypertensive group(98 54±22 34pg/ml) than in mild group(P<0 01).It was positively correlated with mean artery pressure(r=0.657,P<0.01).The plasma of ET in the group of essential hypertension with LVH were higher than in those without LVH(141.03±25.78 VS 85.10±19.91pg/ml,P<0.01).It was positively correlated with left Ventricular mass index in all patients.Conclusion:It is suggested that ET is closely related with the rise of blood pressure and may play a role in the production and development of hypertension and LVH.[