摘要
目的:探讨食管鳞癌淋巴结转移与其CT灌注参数及血管生成的关系。方法:50例食管癌患者行MSCT灌注扫描,采用免疫组织化学SP法检测术后标本中MVD及VEGF的表达。分析食管癌淋巴结转移与CT灌注参数中血容量(BV)、血流量(BF)、平均通过时间(MTT)、表面通透性(PS)及MVD、VEGF表达之间的关系。结果:食管鳞癌CT灌注参数中BF、BV、MTT值在有和无淋巴结转移组中分别为(128.81±50.05)和(105.55±43.18))ml/(100g.min)、(7.64±3.11)和(6.33±1.71)ml/100g、(5.62±1.97)和(7.16±3.32)s,差异均无统计学意义(P>0.05),而PS值在有和无淋巴结转移组分别为(18.32±5.39)和(9.66±2.46)ml/(100g.min),差异有高度统计学意义(P<0.01);以PS值>10ml/(100g.min)为阈值预测淋巴结转移的敏感度、特异度、阳性及阴性似然比分别为95.8%、65.4%、2.77和0.06;VEGF及MVD值与食管鳞癌淋巴结转移有显著正相关关系(r值分别为0.752和0.384,P<0.01)。结论:CT灌注成像有助于食管鳞癌淋巴结转移的术前诊断,其中PS值是最有价值的诊断指标。
Objective:To evaluate the relationship of lymph node metastasis with CT perfusion parameters and angiogenesis in esophageal squamous cell carcinoma. Methods: Multi-detector row spiral CT (MDCT) perfusion was performed in 50 patients with esophageal carcinoma. The micro-vascular density (MVD) and VEGF expression were examined by means of SP immuno-histochemical technique. The correlation of lymph node metastasis with CT perfusion parameters,including blood volume (BV), blood flow (BF),mean transit time (MTT),surface permeability (PS), MVD and VEGF expression were analyzed. Results:The BF,BV and MTT values of esophageal squamous cell carcinoma with and without lymph node metastasis were (128. 81± 50. 05) ml/(100g·min), (7. 64±3. 11) ml/100g, (5. 62± 1. 97) s and (105. 55± 43.18)ml/(100g·min) ,(6.33±1.71)ml/100g,(7.16±3.32)s respectively,with no significant statistical differences (P〉0.05). Significant difference of the PS value [ (18.32 ±5.39) vs (9.66 ± 2.46)ml/(100g · min)] was found between patients with or without lymph node metastasis (P〈0.01). Taking PS value (〉10ml/100g·min) as the threshold for the diagnosis of lymph node metastasis, the sensitivity, specificity, positive and negative likelihood ratio were 95.8%, 65.4%, 2.77 and 0.06 respectively. The lymph node metastasis showed positive correlation to MVD and VEGF expression with r values as 0. 752 and 0. 384 respectively (P〈0.01). Conclusion:CT perfusion imaging is helpful for the preoperative diagnosis of lymph node metastasis in esophageal squamous cell carcinoma,and PS value is the most valuable diagnostic index.
出处
《放射学实践》
2012年第7期750-753,共4页
Radiologic Practice
关键词
食管肿瘤
体层摄影术
x线计算机
灌注成像
淋巴结转移
Esophageal neoplasms
Tomography,X-ray computed
Perfusion imaging
Lymph node metastasis