监测利奈唑胺对临床分离的耐甲氧西林金黄色葡萄球菌的体外抗菌活性

Monitoring the antimicrobial activity in vitro of linezolid on clinical separated methicillin-resistant staphylococcus aureus

目的了解临床分离的耐甲氧西林金黄色葡萄球菌(MRSA)对利奈唑胺的敏感性及对其他抗菌药物的耐药情况,为临床合理选用抗菌药物提供依据。方法收集本院2008年6月至2011年6月期间住院患者各类临床送检标本,进行细菌学培养鉴定,按湖北地区监测网统一方案进行药物敏感性试验,依据CLSI2009年版标准判读结果,用WHONET 5.4软件进行统计数据分析。结果 2008年6月至2011年6月期间共分离出金黄色葡萄球菌297株,其中MRSA 116株。分离出MRSA的标本以痰标本为主,其次为分泌物和血液。MRSA对利奈唑胺、万古霉素、替考拉林敏感率为100%;对复方新诺明、氯霉素敏感率大于80%;对青霉素、苯唑西林100%耐药;对其他药物敏感性较低。结论 MRSA对大部分抗菌药物仍维持较高的耐药率,利奈唑胺与万古霉素、替考拉林一样是为数不多,仍然对MRSA表现较强抗菌活性的药物之一。

Objective To understand the sensitivity of separated methicillin-resistant staphylococcus aureus（MRSA） on linezolid and the drug resistance to other antibiotics,and provide the basis for choosing antimicrobial drugs for clinical use.Methods We collected all kinds of isolated clinical specimens of hospitalized patients from June 2008 to June 2011,which were cultured and identified by bacteriology.According to Hubei area unified monitoring network scheme,we did the drug sensitivity test based on the standard of CLSI2009 edition standard interpretation results,with WHONET 5.4 software for statistical data analysis.Results From June 2008 to June 2011,297 strains of staphylococcus aureus（SAU） were separated,including 116 strains of MRSA.Isolated specimens of MRSA were mostly in sputum samples,followed by secretion and blood.The sensitive rate of MRSA to linezolid,vancomycin,teicoplanin was 100%;and that to compound sulfamethoxazole and chloromycetin was more than 80%;The drug resistance rate of MRSA to penicillin and oxacillin was 100%,and that to other drugs was low.Conclusion The drug resistance of MRSA to most antimicrobial drugs is high,but the sensitive rate of MRSA to linezolid,vancomycin and teicoplanin is high.