幽门螺旋杆菌感染与上消化道症状的相关性研究

Correlation study on helicobacter pylori infection and upper gastrointestinal tract symptoms

目的分析幽门螺旋杆菌(H.pylori)感染与不同上消化道症状出现的相关性。方法 199例患者的胃黏膜标本用来做本次研究,使用Real-time PCR检测H.pylori的保守基因ure以判断H.pylori的感染。结果 199例患者中,H.pylori阳性121例(60.8%),有反酸嗳气症状者65例(32.7%),恶心呕吐者8例(4%),食欲不振者65例(32.7%),慢性腹痛者89例(44.7%)。H.pylori感染与反酸嗳气(χ2=0.22;P=0.64)、恶心呕吐(χ2=0.01;P=0.92)及食欲不振(χ2=1.92;P=0.17)无显著相关性,但H.pylori阳性人群中出现慢性腹痛症状者明显多于H.pylori阴性的人群(χ2=8.33;P=0.004)。结论 H.pylori可能在慢性腹痛症状的出现过程中发挥着潜在的作用。

Objective To investigate the relationship between helicobacter pylori（HP） infection and the development of different upper gastrointestinal tract symptoms.Methods Gastric mucosal from 199 patients were enrolled in this research.We used Real-time PCR to detect the conserved gene ure for diagnosing HP infection.Results Among the 199 patients,121（60.8%）were HP positive,65（32.7%）with acid regurgitation and belching,8（4%）with nausea vomiting,65（32.7%）with anorexia and 89（44.7%）with chronic abdominalgia.No relationship was found between acid regurgitation and belching（χ2=0.22;P=0.64）,nausea vomiting（χ2=0.01;P=0.92）,anorexia（χ2=1.92;P=0.17）and HP infection.However,patients with chronic abdominalgia were more found in HP positive than in HP negative ones（χ2=8.33;P=0.004）.Conclusion H.pylori may play a potential role in the development of chronic abdominalgia.