吲哚胺2，3-双加氧酶和B7分子同源蛋白1在胰腺癌组织中的表达及其临床意义

Clinical significance of lndoleamine 2,3-dioxygenase （IDO） and B7-H1 expressions in pancreatic carcinoma patients undergone pancreatoduodenectomy

目的探讨吲哚胺2，3-双加氧酶（Indoleamine2，3-dioxygenase，IDO）和B7分子同源蛋白1（B7homologousprotein1，B7-H1）在胰腺癌中的表达情况，分析其与临床病理参数及术后预后的关系。方法收集95例行胰十二指肠切除术的胰腺癌患者的临床病理资料，检测ID0和B7-H1的表达，分析其与临床病理参数及预后的关系。结果胰腺癌中IDO和B7-H1的表达强度较正常胰腺均显著升高（P〈0．05）。两者均与肿瘤病理分级、TNM分期正相关（P〈0．05），并与胰腺癌预后具有明显关联。但是，调整病理分级、TNM分期后，只有IDO／B7-H1联合表达可作为评估胰腺癌患者预后的预测指标。结论胰腺癌组织中IDO和B7-H1阳性表达与胰腺癌的恶性程度密切相关，ID0／B7-H1的联合表达可作为胰腺癌患者术后的预后独立预测指标。

Objective To analyze the relationship between expressions of Indoleamine 2,3-diox- ygenase （IDO） and BT-H1 with clinico-pathological features and their prognostic significance in pan- creatic cancer （PC）. Method 95 patients who underwent radical pancreaticoduodenectomy for PC were studied. The IDO and BT-H1 expressions in tissue specimens were determined by immunohisto- chemistry. Results IDO and B7-H1 expressions were higher in pancreatic carcinoma tissues than in normal pancreatic tissues （P〈0. 05）. IDO and B7-H1 expressions positively and significantly correla- ted with pathological grades and tumour-node-metastasis （TNM） stages （P〈0. 05）. They were prog- nostic of poor cancer-specific survival. After adjusting by the Cox proportional hazards regression models （P d0. 05）, only a combined IDO/B7-H1 expression served as an independent prognostic marker. Conclusions IDO and B7-H1 were expressed in PC, and they were important markers for malignant progression of PC. A combined IDO/B7-H1 expression served as an independent prognostic marker for PC.