骨髓间充质干细胞在肝脏疾病治疗中的应用

Using bone marrow mesenchymal stem cells to treat liver diseases

原发性肝癌大多于肝纤维化、肝硬化的基础上发生，最终导致肝功能衰竭和全身转移。手术切除是肝癌的首选治疗方式，介入治疗和肝移植也是治疗终末期肝癌的手段。然而，肝部分切除和介入治疗往往制约于肝功能的失代偿。肝移植由于缺乏供体和价格昂贵临床亦难以广泛开展。近十多年来，骨髓间充质干细胞（BMSC）研究在医学领域取得了令人瞩目的成就。本文就骨髓间充质干细胞在肝脏疾病治疗中的应用作一综述。

Primary hepatocellular carcinoma progres- ses from liver fibrosis and cirrhosis to eventually result in liver failure and distant metastasis. Surgical resection is the preferred method of treatment for liver cancer while inter- ventional treatment and liver transplantation are the choices to treat end-stage liver cancer. Unfortunately, partial hepa- tectomy and interventional treatment are not ideal due to the resulting consequence of hepatocyte dysfunction. Extensive clinical application of liver transplants is limited by the lack of available donors and high costs. Over the past decade, re- searches on bone marrow mesenchymal stem cells （BMSCs） have made remarkable achievements in the medical field. In this review, we summarize the recent progress of BMSCs in the treatment of liver diseases.