α-氰基丙烯酸正丁酯医用黏合剂闭合皮肤切口的效果观察

Butyl cyanoacrylate for the dose of skin incisions

目的观察α-氰基丙烯酸正丁酯医用黏合剂闭合普通外科择期手术Ⅰ、Ⅱ类皮肤切口的效果与安全性。方法2009年10月至2011年6月按拟定的入选标准和排除标准，选择普通外科手术患者31例，签署知情同意书后入组。在手术结束之际关闭皮肤切口时，用4-0可吸收线缝合手术切口处的筋膜、皮下组织层后，使用α-氰基丙烯酸正丁酯医用黏合剂闭合皮肤切口。结果本组31例，切口长度12～180mm，平均（32±32）mm。术后第1天切口发红2例，切口少许渗液1例，均在第2天消失。术后均无发热。术后第1天有3例中度疼痛，术后第1天、第3天、第5天分别有28例、18例、5例诉轻度疼痛。切口愈合时间5～9d，平均（6．3±1．1）d。所有切口均一期甲级愈合。结论α-氰基丙烯酸正丁酯医用黏合剂闭合非感染手术的皮肤切口是安全有效的，并具有炎症反应轻微、瘢痕小、感染少的优点。

Objective To observe the effect and safety of butyl cyanoacrylate used to close type Ⅰ and Ⅱ skin incisions in non-emergency operations of general surgery. Methods We have enrolled 31 cases with written consent. Upon completion of the surgery butyl cyanoacrylate was used to close skin incisions instead of surgical sutures after suturing subcutaneous tissue with 4-0 absorbable thread. Results The length of incisions was 12 - 180 mm （32±32） mm. On the first post-op day, 2 cases had redness and 1 had some effusion within the incision subsiding on the second day, there were no fever. Moderate pain was recorded in 3 cases on the first day after operation. The number of cases reporting slight pain on the first day, third day and fifth day were respectively 28,18 and 5. The others had no any pain. The healing time was （6.3±1.1 ） d, there was no delayed healing, no other complications. Conclusions The tissue adhesive method, using butyl cyanoacrylate is of value in closing type Ⅰ and Ⅱ skin incisions in general surgery. It has the advantage of reducing scar and inflammation.