Lewis酸离子液体催化合成2′,4′,6′-三甲基苯乙酮

Synthesis of 2′,4′,6′-Trimethylacetophenone Catalyzed by Lewis Acid Ionic

合成了四种Lewis酸离子液体,考察其对均三甲苯和乙酸酐的Friedel-Crafts酰基化反应的催化活性后,选定以[Emim]Br-AlCl3为溶剂兼催化剂合成2′,4′,6′-三甲基苯乙酮。探讨了AlCl3的摩尔分数、反应时间、反应温度和反应物摩尔比等因素对产物收率的影响。当AlCl3摩尔分数x(AlCl3)=0.67,n([Emim]Br-AlCl3):n(均三甲苯):n(乙酸酐)=1:3:1,反应温度80℃,反应时间6 h时,产物收率最高可达73.4%。

Four kinds of Lewis acid ionic liquids were prepared, and their catalytic activities for Friedel- Crafts acylation of mesitylene and acetic anhydride were measured. The impacts of factors on the reaction were explored when [Emim]Br-AlCl3 was chosen as the catalyst and solvent. Under the conditions of 80 ℃, x（A1Cl3）-0.67 and n（[Emim]Br-AlCl3）： n（1,3,5-trimethylbenzene）：n（acetic anhydride）=1：3：1, the yield of the product could reach 73.4% after 6 h reaction.