亚氨基吡格列酮的新合成方法研究

The Study of Novel Synthetic Method of Imi pioglitazone

以4-(2-(5-乙基吡啶-2-基)乙氧基)苯甲醛为原料,通过还原、氯化、缩合、溴化、环合五步反应得到亚氨基吡格列酮,总收率57%。此方法原料易得,反应条件温和,操作过程简单,未使用毒性较大的丙烯酸甲酯,产品收率较高,有利于工业化生产。

A novel synthetic method of 5-{4-[2-（5-Ethyl-2-pyridyl）ethoxy]benzyl}-2-imino-4-thiazolidin-one can be got through reduction chloration condensation bromination and cyclization when the 4-[2-（5-Ethyl-pyridin-2-yl）-ethoxy]-benzaldehyde was used as raw material.The total yield was achieved to 57%.Comparing to other ordinary methods.this synthetic route had many advantages,such as cheap raw materials,mild reaction conditions,simple opration,and higher yield,especially high toxic methyl acrylate was not used,so it had broad application prospects in industry production.