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胆固醇转运蛋白NPC1L1的研究进展 被引量：3

The Development of the Key PNPC1L1 in Cholesterol Transport
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摘要 NPC1L1是近年来人们研究高脂血症的重点内容,该蛋白已被证实在胆固醇的肠道吸收和胆汁分泌中发挥了关键作用。NPC1L1调节体内胆固醇的生物合成,是维持生物体胆固醇动态平衡的重要因素,同时也是新型降脂药物依泽替米贝的作用靶点。 Niemann-Pick C1 Like 1 NPC1L1 has recently become a research emphasis in hyperlipidemia. It has been identified as an essential protein in the intestinal cholesterol absorption and bile secretion. NPC1Llcan maintain the whole body cholesterol homeostasis by regulatirlg cholesterol biosynthesis and it is the target of ezetimibe.
作者 张艳平 许崇利 刘霞 高飞 武蓉 欧阳红生 逄大新 许崇波
机构地区 大连大学医学院 吉林大学畜牧兽医学院 吉林化工学院环境与生物工程学院 南京师范大学生命科学院
出处 《中国动物检疫》 CAS 2012年第6期76-79,共4页 China Animal Health Inspection
基金 国家科技支撑计划(2011BA115B02)
关键词 NPC1L1 肠道胆固醇吸收 胆固醇转运 Niemann-Pick C1 Like 1 ： Intestinal cholesterol absorption Cholesterol transport
分类号 Q548.1 [生物学—生物化学]
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参考文献27

  • 1Altmann S W, Davis Jr H R, Zhu L J. Niemann-Pick C1 Like 1 Protein Is Critical for Intestinal Cholesterol Absorption[J]. Science, 2004, 303( 5661 ): 1201-1204.
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  • 3Davies J P, Brynn L, IoannouY A. Evidence for a Niemann- Pick C NPC Gene Family: Identification and Characterization of NPC1L1 [J]. Genomics, 2000, 65(2): 137-145.
  • 4Haruaki N. Niemann-Pick C1-Like 1 : A Key Player in Intestinal Cholesterol Absorption[J]. Yonago Acta medica, 2010, 53 (2): 29- 36.
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二级参考文献163

  • 1梁磊,庹勤慧,朱炳阳,匡双玉,罗迪贤,许灿新,廖端芳.依泽替米贝对泡沫细胞胆固醇转运的影响[J].国际病理科学与临床杂志,2006,26(2):93-98. 被引量：1
  • 2Repa J J, Li H, Frank-Cannon T C, et al. Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse[J]. J Neurosci, 2007, 27(52): 14470-14480.
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共引文献15

同被引文献35

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  • 6Altmann SW, Davis HR Jr, Zhu Ll,et al. Niemann-Piek C1 Like I pro- tein is critical for intestinal cholesterol absorption [ J ]. Science, 2004, 303 : 1201 - 1204.
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  • 8Yu L, Bharadwaj S, Brown JM, et al. Cholesterol-regulated transloca- tion of NPCILI to the cell surface facilitates free cholesterol uptake[ J ]. J Biol Chem ,2006,281:6616 - 6624.
  • 9Ge L, Wang J, Qi W, et al. The cholesterol absorption inhibitor ezetimibe acts by blocking the sterol-indueed internalization of NPCIL1 [J~. Cell Metab,2008, 7:508 -519.
  • 10Ge L, Qi W, Wang LJ,et al. Flotillins play an essential role in Nie- mann-Pick Cl-like l-mediated cholesterol uptake[ J]. Proc Natl Acad Sci USA ,2011,108:551 - 556.

引证文献3

二级引证文献25

中国动物检疫
2012年 第6期

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