ER-β、MEK-2、p-ERK在子宫内膜异位症组织中的表达及意义被引量：3

Expression of ER-β,MEK-2 and p-ERK in endometriosis

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摘要目的:探讨雌激素受体ER-β与细胞信号传导通路丝裂原活化蛋白激酶(MAPK)上游激活酶MEK-2和下游激活酶p-ERK在子宫内膜异位症(EMs)发病机制中的作用。方法:采用免疫组化S-P法检测46例EMs患者在位及异位内膜、40例正常内膜组织中ER-β、MEK-2和p-ERK的蛋白表达。结果:ER-β、MEK-2和p-ERK在异位内膜和在位内膜中表达高于正常内膜,差异有显著性意义(P<0.01),异位内膜表达高于在位内膜,差异具有显著意义(P<0.01);ER-β和MEK-2、p-ERK在正常子宫内膜、在位内膜和异位内膜中表达呈正相关(r=0.628,P<0.01;r=0.559,P<0.01)。MEK-2和p-ERK在正常子宫内膜、在位内膜和异位内膜中表达呈正相关(r=0.699,P<0.01)。结论:ER-β、MEK-2和p-ERK在EMs组织中高表达并呈正相关,MAPK信号通路可能与ER-β相互作用,在EMs的发生发展中起着重要作用。 Objective： To detect the expression of estrogen receptor ER-beta and MAPK upstream activate enzymes MEK-2 and down- stream activate enzymes p-ERK in the pathogenesis of endometriosis （EM）. Methods： Immunohistochemical S-P method was employed to detect the expression of ER-β, MEK-2 and p-ERK in eutopic and eetopic endometrium of patients with EMs （46 cases） and normal controls （40 cases）. Results： The expression level of ER-β, MEK-2 and p-ERK in the ectopic and eutopic endometrium of patients were significantly higher than those in control group（P〈0.01）, and the expression level in ectopie endometrium was higher than those in eutopic endometrium （P〈0.01）. There were positive correlation between ER-β, MEK-2 and p-ERK in the ectopic endometrium, eutopic en- dometrium and the normal controls（r=0.628,P〈0.01 ;r=0.559, P〈0.01）. Conclusion： ER-β, MEK-2 and p-ERK are abnormally overex- pressed in endometriosis, and they are positive correlation. MAPK signaling pathways, which is related with estrogen receptor ER-beta, may play an important role in the pathophysiology of EMs.

作者郭祥翠朱颖军林琬君陈震

机构地区天津医科大学研究生院天津市中心妇产科医院妇科

出处《天津医科大学学报》 2012年第2期201-204,216,共5页 Journal of Tianjin Medical University

关键词子宫内膜异位症雌激素受体Β 丝裂原活化蛋白激酶 endometriosis ER-β MAPK

分类号 R711.71 [医药卫生—妇产科学]

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