突发性耳聋患者外周血内皮祖细胞的变化

Number of endothelia progenitor cells from peripheral blood in patients with sudden sensorineural hearing loss

目的:探讨突发性耳聋患者外周血中内皮祖细胞(EPCs)数量变化及增殖集落变化情况。方法:测定突发性耳聋患者和听力正常健康人外周血中EPCs数量及培养7 d后增殖集落数量。结果:突发性耳聋组外周血中EPCs计数为(36.5±2.58)个/20万单个核细胞,听力正常健康人EPCs计数为(85.3±6.55)个/20万单个核细胞,EPCs增殖集落计数分别为(2.01±0.31)个和(3.80±1.05)个,两者比较差异具有统计学意义(P<0.01)。结论:突发性耳聋患者由于EPCs数量及增殖集落数量下降,在机体修复过程中不能满足要求而引起耳聋等临床症状。

Objective： To investigate the number of endothelia progenitor cells （EPCs） from peripheral blood in patients with sudden sensorineural hearing loss （SSHL） and the proliferative number of EPCs colonies. Methods： Number of EPCs from peripheral blood and number of proliferative colonies of EPCs after 7 d were measured and comparison was made between SSHL group and the healthy group. Results： The number of EPCs reduced significantly in SSHL group compared with contrast group, they were （36.5±2.58）/200×10^3 cells and（85.3±6.55）/200×10^3 cells respectively. The number of proliferative colonies of EPCs were（2.01 ±0.31） in SSHL group and （3.80±1.05） in normal group （P〈0.01）. Conclusion： Because the number of EPCs and the number of proliferative colonies of EPCs significantly lessen in patients with SSHL, EPCs cannot satisfy the body requirement during the process of restoration and result in the symptom of hearing loss.