原发性肾小球肾炎外周血细胞粘附分子浓度变化及其临床意义

Clinical significance of adhesion molecule in primary glomerular nelphritis

目的 探讨原发性肾小球病变患者外周血粘附分子Ｐ选择素（ＣＤ６２Ｐ）与细胞表面糖蛋白（ＣＤ４４）的表达特征及其临床意义。方法 采用流式细胞术对９０例原发性肾小球肾炎患者外周血ＣＤ６２Ｐ和ＣＤ４４ 进行了检测分析，以３０例正常人作为对照。结果 原发性肾小球肾炎患者ＣＤ６２Ｐ和ＣＤ４４表达均较正常组显著增高（Ｐ＜ ０．０１），其中尿毒症组ＣＤ４４阳性细胞数增高极为显著，ＩｇＡ肾病组ＣＤ６２Ｐ和ＣＤ４４表达均较其它肾脏疾病组降低（Ｐ＜ ０．０５），ＣＤ６２Ｐ和ＣＤ４４表达为ｒ＝ ０．４１，呈正相关（Ｐ＜ ０．０５）。结论 ＣＤ６２Ｐ和ＣＤ４４ 在原发性肾小球病变患者外周血中表达异常，在肾脏疾病发展及病情变化过程中起重要作用。

Objective To study the expression and significance of adhesion molecule in nephroses,including P selectin(CD62P) and glucoprotein (CD44).Method The expressions of CD62P and CD44 in blood of primary glomerular nephritis were assessed by flow cytometry,being compared with the control.Results The levels CD62P and CD44 in patients showed higher than those in control ( P <0.01),CD44 in chronic renal failure group was especially high.compared with other nephropathy groups,expressions of CD62P and CD44 in IgA nephropathy group were lower.Expressions of CD62P and CD44 in patients were correlated with each other (r=0.41, P <0.05).Conclusion Expressions of CD62P and CD44 in the bood of glomerular nelphritis patients were abnormal,The two adhesion molecules may play important roles in progress of renal disease. [