摘要
目的探讨血清miR-34a在诊断宫颈鳞癌淋巴结转移的价值。方法 65例宫颈鳞癌患者,其中伴淋巴结转移者25例(A组),不伴淋巴结转移者40例(B组),并选择健康体检妇女15例作为对照组。采用实时荧光定量PCR测定血清miR-34a水平,并绘制ROC曲线分析血清miR-34a与淋巴结转移的关系。结果 A组、B组、对照组血清miR-34a相对表达量无差异(P>0.05)。血清miR-34a相对表达量与宫颈癌分期无关(P>0.05),与淋巴结转移无关(P>0.05)。结论 miR-34a对判断宫颈癌有无淋巴结转移不敏感。
Objective To investigate the value of serum microRNA-34a （miR-34a） in the diagnose of lymph node metastasis of squamous cervical cancer. Methods Sixty-five patients with squamous cervical cancer were enrolled in the study,including 25 cases with lymph node metastasis （LNM） （group A） and 40 cases without LNM （group B）, while 15 healthy women as controls. The level of seruin miR-34a was detected by real-time qRT-PCR, and its relationship with LNM was analyzed by ROC curve. Results There was no significant difference in serum miR-34a expression among group A,group B and the controls（P 〉0.05 ）. Serum miR-34a level wasn＇t correlated with LNM or staging of cervical cancer（P 〉 0.05 ）. Conclusion Serum miR-34a is not a sensitive index for diagnosis of LNM in cervical cancer patients.
出处
《广西医学》
CAS
2012年第6期663-666,共4页
Guangxi Medical Journal
基金
广西自然科学基金(2011GXSFA018184)
广西研究生教育创新计划资助课题(2011105981002M182)
