各型痴呆患者血脂水平及其高血压、冠心病、糖尿病检出率的比较

A Comparison of Plasma Lipids Level,Detection Rates of Hypertension, Coronary Heart Disease,Diabetes Mellitus Among Various Types of Dementia Patients

目的探讨各型老年期痴呆患者血脂水平变化特点。方法选择阿尔茨海默病(AD组,43例)、血管性痴呆(VD组35例)、帕金森痴呆(PDD组39例)及非痴呆(34例)患者,检测各组空腹总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)、脂蛋白α的水平,并对比4组高血压、冠心病、糖尿病的检出率。结果 AD、VD、PDD 3组各项血脂水平与非痴呆组比较差异无统计学意义(P>0.05)。各组高血压、糖尿病检出率比较差异无统计学意义(P>0.05);非痴呆组冠心病检出率高于各痴呆组(P<0.05)。结论血脂代谢异常与各型痴呆无明显关联,各痴呆组在高血压、冠心病、糖尿病检出率相近。

Objective To investigate the features of plasma lipids level among various types of senile dementia patients. Methods Forty-three patients with Alzheimer＇s disease（AD group） ,35 patients with vascular dementia（VD group） ,39 cases of Parkinson＇s disease with dementia（PDD group） and 34 normal controls（ NC group） were enrolled in the study. The levels of fasting total cholesterol （ TC ）, total triglyceride （ TG）, high density lipoprotein-cholesterol （ HDL-C）, low density lipoprotein-cholesterol （ LDL-C ）, apolipoprotein A1 （ ApoAl ）, apolipoprotein B （ ApoB ） and lipoprotein ct were detected, respectively. The detection rates of hypertension, coronary heart disease （ CHD）, diabetes mellitus（DM） were compared among the four groups. Results No significant difference was found in the plasma lipids level between NC group and AD group or VD group or PDD group （ all P 〉 0.05 ）. There was no significant difference in the detection rates of hypertension and DM among four groups （P 〉 0.05）, and the detection rate of CHD was higher in NC group than in others three groups （P 〈 0.05 ）. Condusion Abnormal plasma lipids is not correlated with each type of dementia. Various types of dementia patients have the similar detection rates of hypertension,CHD and DM.