亲属肾移植父母供肾对移植肾功能的影响

Study on influence of renal function in transplantation with donor kidney from parents of patients

目的研究亲属肾移植患者父母供肾对肾移植受者移植肾功能的影响。方法对2009年12月前行肾移植手术的父母为供体的86例亲属肾移植受者于2011年12月检测群体反应性抗体(PRA)和肾功能(血肌酐和尿素氮),并以子辈供肾移植肾功能作对照。结果以父母为供体的86例亲属肾移植受者中,42例患者肾功能正常,占48.84%(42/86);44例患者肾功能不正常,占51.16%(44/86)。父亲给子女供肾38例,肾功能正常患者22例,不正常患者16例;母亲给子女供肾48例,肾功能正常患者20例,不正常患者28例。父母分别给子女供肾对移植肾功能的影响有显著性差异(χ2=6.649,P<0.01)。大于或等于55岁和小于55岁的父母供肾移植肾功能无显著性差异(χ2=1.254,P>0.05)。42例肾功能正常的肾移植受者3例PRA阳性,44例肾功能不正常患者12例PRA阳性,两者间有显著性差异(χ2=4.73,P<0.05)。父母供肾与子辈供肾对移植肾功能的影响具有非常显著性差异(χ2=7.025,P<0.005)。结论子辈与父辈作为肾移植供体相比,高龄供肾对移植肾长期存活具有一定的影响,PRA影响移植肾功能。

Objective To study the influence on renal function in renal transplantation with donor kidney from parents.Methods Eighty six recipients received renal transplant from parents before December,2009 were examined with Panel reactive antibody（PRA） and serum levels of creatinine and urea nitrogen in December 2012,and patients received renal donation from offspring as controls.Results The function of renal transplant was normal in 42 recipients（42/86,or 48.84%）.The function of transplanted kidney was abnormal in remaining 44 recipients（44/86,51.16%）.Thirty eight patients received kidneys from father,among them 22 showed normal renal function,and 16 showed abnormal renal function.Forty eight patients received kidneys from mother,among them 20 showed normal renal function,and 28 showed abnormal renal function.There was si0gnificant difference in renal function between transplanted kidneys from father or mother（χ2=6.649,P0.01）.There was no significant difference between age of donors over 55 years or less than 55 years（χ2=1.254,P0.05）.PRA detection showed positive result in 3 of 42 recipients with normal renal function group;PRA detection showed positive result in 12 of 44 recipients with abnormal renal function group,and there was no significant difference between these two groups（χ2=4.73,P0.05）.There was significant difference in renal function between parents transplanted group and offspring transplanted group（χ2=7.025,P0.005）.Conclusion In comparison with offspring and parents donation,there is much influence on renal function if transplant is from elderly donor,and the presence of PRA can influence the renal function of transplanted kidney.