摘要
目的:研究国产沉香的化学成分。方法:通过多种色谱手段,对国产沉香的石油醚及乙醇提取物进行化学成分分离,采用现代波谱技术对化合物的结构进行鉴定。结果:从国产沉香中分离得到9个化合物,分别鉴定为3,3,7-trimethyltri-cycloundecan-8-one(1),longifolene(2),norlongilactone(3),caryophyllenol-II(4),humulene diepoxide A(5),kobusone(6),(-)-bornyl ferulate(7),(24R)-24-ethylecholesta-4,22-dien-3-one(8),(24R)-24-3-ono-4-en-sitosterone(9)。结论:化合物2~9均为首次从国产沉香中分离得到的化合物。化合物1~6为倍半萜类化合物,化合物7为单萜衍生物,化合物8,9为甾类衍生物。
The column chromatography on silica gel, semi-preparative HPLC were used to separate and purify the compounds from the petroleum ether and ethanol extract of Aquilaria sinensis. Nine compounds were isolated. On the basis of their spectroscopic data, the structures were identified as 3, 3, 7-trimethyltricycloundecan-8-one (1), longifolene (2) , norlongilactone (3), caryophyl- lenol-Ⅱ (4), humulene diepoxide A (5), kobusone (6), ( - ) -bornyl ferulate (7), (24R) -24-ethylcholesta-4, 22-dien-3-one (8), (24R)-24-3-ono-4-en-sitosterone (9). Compounds 2-9 were isolated from this plant for the first time. compounds 1-6 are sesquiterpe- nes, compound 7 is a monoterpene derivative, compound 8 and 9 are steroids.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2012年第13期1973-1976,共4页
China Journal of Chinese Materia Medica
基金
国家"重大新药创制"科技重大专项(2009ZX09301-03-03)
国际科技合作项目(2009DFA32250)
国家民委科研项目(09ZY0142)
关键词
国产沉香
倍半萜类
单萜类
甾体类
Aquilaria sinensis
sesquiterpenes
monoterpene
steroids