国产沉香中的倍半萜类和单萜类化学成分

Sesquiterpenes and monoterpene from Aquilaria sinensis

目的:研究国产沉香的化学成分。方法:通过多种色谱手段,对国产沉香的石油醚及乙醇提取物进行化学成分分离,采用现代波谱技术对化合物的结构进行鉴定。结果:从国产沉香中分离得到9个化合物,分别鉴定为3,3,7-trimethyltri-cycloundecan-8-one(1),longifolene(2),norlongilactone(3),caryophyllenol-II(4),humulene diepoxide A(5),kobusone(6),(-)-bornyl ferulate(7),(24R)-24-ethylecholesta-4,22-dien-3-one(8),(24R)-24-3-ono-4-en-sitosterone(9)。结论:化合物2～9均为首次从国产沉香中分离得到的化合物。化合物1～6为倍半萜类化合物,化合物7为单萜衍生物,化合物8,9为甾类衍生物。

The column chromatography on silica gel, semi-preparative HPLC were used to separate and purify the compounds from the petroleum ether and ethanol extract of Aquilaria sinensis. Nine compounds were isolated. On the basis of their spectroscopic data, the structures were identified as 3, 3, 7-trimethyltricycloundecan-8-one （1）, longifolene （2） , norlongilactone （3）, caryophyl- lenol-Ⅱ （4）, humulene diepoxide A （5）, kobusone （6）, （ - ） -bornyl ferulate （7）, （24R） -24-ethylcholesta-4, 22-dien-3-one （8）, （24R）-24-3-ono-4-en-sitosterone （9）. Compounds 2-9 were isolated from this plant for the first time. compounds 1-6 are sesquiterpe- nes, compound 7 is a monoterpene derivative, compound 8 and 9 are steroids.