碘钠同向转运体在新疆维吾尔族甲状腺乳头状癌中的表达及其临床意义

The expression and clinical significance of NIS in Xinjiang Uygur papillary adenocarcinoma

目的研究钠碘同向转运体(NIS)在新疆维吾尔族甲状腺乳头状癌组织标本及转移淋巴结组织中的表达及其临床意义。方法选取手术切除后经临床病理证实的新疆维吾尔族甲状腺乳头状癌存档标本72例,采用免疫组织化学检测NIS在甲状腺癌组织、癌旁组织以及转移淋巴结组织中的表达,分析NIS在甲状腺癌组织中的分布特点及其与临床病理各参数间的相互关系。结果 (1)甲状腺乳头状癌组织中NIS表达阳性率为80.56%,在癌旁正常甲状腺组织中的NIS阳性表达率为30.56%,差异有统计学意义(P<0.05);(2)Ⅰ、Ⅱ期甲状腺癌组织中NIS表达阳性率为87.88%,Ⅲ、Ⅳ期甲状腺癌组织中NIS表达阳性率为74.36%,随着临床分期的递增,甲状腺癌组织中NIS表达阳性率出现降低趋势,但差异无统计学意义(P>0.05);(3)在有淋巴结转移和无淋巴结转移的甲状腺乳头状癌患者中NIS表达阳性率分别为68.97%和42.86%,差异有统计学意义(P<0.05);(4)在肿瘤直径≤2cm和>2cm的甲状腺乳头状癌组织中NIS表达阳性率分别为93.02%和62.07%,差异有统计学意义(P<0.05)。结论新疆维吾尔族甲状腺乳头状癌组织中NIS的表达随着临床分期增加而逐渐降低,在有淋巴结转移患者中NIS的表达显著增加,同时随着瘤体体积的增大NIS的表达显著下降。

Objective To analyze the clinical significance of sodium/iodide symporter （NIS） by investigating the expression of which in tissue of papillary adenocarcinoma and metastatic lymphonodes of Xinjiang Uygur nationality. Methods Seventy two cases of paraffin slices made from Xinjiang Uygur patients con firmed to be papillary adenocarcinoma by clinical pathology were collected and tested the expression of NIS in tissue of carcinoma, beside the carcinoma and metastatic lymphonodes by means of immunohistochemistry, analyzed the distribution and the correlation with pathologic parameters. Results expression rate of NIS in tissue of carcinoma, beside the carcinoma were 80.56%, 30. respectively; （2） The expression of NIS in stage Ⅰ , Ⅱ was 87.87%, and which was 74. （1） 6H 36% The positive and 56.94% in sta IV. With the clinical stage increments, in thyroid cancer tissue ,the expression rate of NIS decrease ge Ⅲ, d, but the difference was not statistically significant （P 〉0.05） ; （3） The positive rates of NIS expression in pa- tients with papillary thyroid carcinoma with lymph node metastasis and without lymph node metastasis- were 68.97% and 42.86%, the difference was statistically significant （P 〈0.05）. （4） The positive rates of NIS expression in thyroid papillary carcinoma with tumor diameter≤2 cm and 〉2 cm were 93.02% and 62.06%, the difference was statistically significant （P 〈0. 05）. Conclusion The expression of NIS in pa- pillary adenocarcinoma in Xinjiang Uygur patients deceases with the growth of disease stage and diameter of the tumor, apparently increases in patients with lymphonodes metastases.