延边农村男性居民GGT异常及其相关因素调查

Distribution of gamma-glutamyl transferase and its correlated factors in rural men of Yanbian area:a cross-sectional study

目的调查延边农村地区不同民族男性居民γ-谷氨酰转肽酶(GGT)分布特征及其相关因素。方法于2009年8—9月对本地区30～70岁常住男性居民2 001人进行现况调查。结果朝鲜族及汉族的GGT的自然对数平均水平分别为(3.55±0.86)和(3.27±0.72)mmol/L,其异常者检出率分别为25.5%(260/1 018)和13.2%(130/983),朝鲜族的GGT平均水平及其异常者检出率均明显高于汉族(F=69.366,χMH2=51.408,P<0.000);30岁～、40岁～、50岁～、60岁～、70岁～GGT异常检出率分别为28.0%(30/107)、31.8%(102/321)、26.1%(96/368)、17.9%(29/162)及5.0%(3/60),差异有统计学意义(χ2=18.788,P<0.01);单因素分析结果表明,GGT异常与年龄、文化程度、饮酒、吸烟、高血压、单纯舒张期高血压(IDH)及收缩期高血压合并舒张期高血压(SDH)等因素相关;多因素分析结果表明,GGT异常与民族、年龄、饮酒频率、高血压、SDH、IDH和单纯收缩期高血压(ISH)密切相关。结论延边地区朝鲜族居民GGT异常的患病危险明显高于汉族;GGT异常与年龄、饮酒频率、高血压及其不同亚型密切相关,其中饮酒频率对GGT异常的影响有明显的计量反应关系。

Objective To investigate the distribution of gamma-glutamyl transferase（GGT） and its correlated factors in rural men of Yanbian area.Methods A cross-sectional study was carried out in 2 001 residents aged 30-70 years.Results The level of the natural logarithm GGT among Korean men（3.55±0.86） was significantly higher than among Han men（3.27±0.72,F=69.366;P0.000）,and the prevalence of GGT disorder in Korean men（25.5%,260/1 018） was significantly higher than in Han men（13.2%,[130/983],χ2MH=51.408;P0.000）.Single factor analyses revealed that age（χ2k=18.788,P0.01）,education level（χ2k=8.387,P0.01）,drinking and smoking（χ2k趋势=33.876,P0.000;χ2H趋势=30.527,P0.000）,hypertension（χ2k=13.922,P0.000;χ2H=16.629,P0.000）,isolated diastolic hypertension（IDH）（χ2k=9.363,P0.01;χ2H=8.219,P0.01） and systolic hypertension（SDH）（χ2k=11.276,P0.01;χ2H=14.422,P0.000） were correlated factors for GGT disorder;multiple factor analyses showed that nationality（Korean）,age,alcohol drinking,hypertension,SDH,IDH,and isolated systolic hypertension（ISH） were correlated factors for GGT disorder（P0.05）,and a dose-response relationship was observed between GGT disorder and alcohol drinking.Conclusion The prevalence of GGT disorder had significant ethnic difference.The prevalence of GGT disorder was positively correlated with age,alcohol drinking,hypertension,SDH,IDH,and ISH（P0.05） among men in the area,and dose-response relationship was sobserved between GGT disorder and alcohol drinking.