苦碟子注射液治疗冠心病心绞痛的Meta分析

Meta-analysis of Kudiezi Injection in the Treatment of Coronary Heart Disease Angina

目的:评价苦碟子注射液治疗冠心病心绞痛的疗效与安全性。方法:检索并选取国内公开发表的有关苦碟子注射液治疗冠心病心绞痛的随机临床对照试验文献,应用Jadad评分法进行质量评价,并进行Meta分析。结果:共有9项研究符合纳入标准。与对照组比较,治疗组苦碟子注射液治疗冠心病心绞痛临床疗效合并比值比(OR)=11.67,合并的OR95%CI上下限均>1,显著性检验Z=7.28,P<0.00001,菱形完全处于垂直线右侧。结论:治疗组苦碟子注射液治疗冠心病心绞痛的疗效优于对照组,但由于纳入的研究数量少、质量低,该疗效评价结果尚需高质量、大样本的随机双盲对照试验的验证。

OBJECTIVE： To evaluate therapeutic efficacy and safety of Kudiezi injection in the treatment of coronary heart dis- ease angina. METHODS： Domestic published literatures about RCTs of Kudiezi injection in the treatment of coronary heart disease angina were retrieved and selected. Jadad score was used to evaluate the quality of literatures, and the quality of statistical analysis was conducted using Meta-analysis. RESULTS： 9 studies met inclusion criteria. Compared with control group, ratio of clinical effi- cacy of Kudiezi injection in the treatment of coronary heart disease angina （OR merger= 11.67） and OR merger 95 % C1 both were more than 1, significant test Z=7.28 （P〈0.000 01）, the diamond was completely on the right of vertical line. CONCLUSION： Therapeutic efficacy of Kudiezi injection in the treatment of coronary heart disease angina is better than control group. However, a small number of low quality studies are included, and the results of efficacy evaluation still need the verification of randomized dou- ble-blind controlled trial of high-oualitv large-scale samnle.