喷雾干燥法制备β-环糊精/香兰素微胶囊

Microencapsulation of Vanillin by Spray-drying with β-Cyclodextrin

采用单因素实验对喷雾干燥法制备β-环糊精/香兰素微胶囊进行研究,以微胶囊的包埋率和装载量为指标优选出最佳的工艺条件为:ρ(β-环糊精)=79.5 g/L,n(香兰素)∶n(β-环糊精)=0.8∶1.0,V(无水乙醇)∶V(水)=1∶10,进风温度130℃,进风速度3.9 m/s,物料流量15 mL/min,得到产品包埋率和装载量分别是69.1%和10.6%。红外光谱结果表明,香兰素与β-环糊精存在分子间相互作用。热重-差热分析结果表明,微胶囊的形成提高了香兰素的热稳定性。粒度分析显示,在50 d存放期间,β-环糊精的平均粒径变化值为0.14～1.2μm,而产品的平均粒径变化值为0.011～0.22μm,后者比前者小,进一步印证了香兰素与β-环糊精形成了超分子微胶囊。

The preparation ofβ-cyclodextrin/vanillin microcapsules through spray-drying method has been investigated by the evaluation of loading efficiency and loading rate of the microcapsules. The optimal production conditions are as follows ： p （ β-cyclodextrin ） = 79.5 g/L, n （ vanillin ） ： n （β- cyclodextrin） = 0. 8：1.0, V（ anhydrous ethanol） ： V（water） = 1 ： 10, inlet temperature 130 ℃, drying air speed 3.9 m/s, flow rate 15 mL/min. The loading efficiency and loading rate of the product were 69. 1% and 10.6% , respectively. FTIR spectra were used to demonstrate the intermolecular interaction between vanillin and fl-cyclodextrin. TG-DSC results confirmed that the thermal stability of vanillin was improved after being encapsulated by β-cyclodextrin. The particle size analysis suggests that the variation value of the average particle size of β-cyclodextrin was within the range of 0. 14 - 1.2 μm and that of the product was within the range of 0. 011 - 0.22 μm during 50 days＇ storage,the latter being much smaller than the former, which further verified the fabrication of supramolecular microcapsules.