摘要
采用单因素实验对喷雾干燥法制备β-环糊精/香兰素微胶囊进行研究,以微胶囊的包埋率和装载量为指标优选出最佳的工艺条件为:ρ(β-环糊精)=79.5 g/L,n(香兰素)∶n(β-环糊精)=0.8∶1.0,V(无水乙醇)∶V(水)=1∶10,进风温度130℃,进风速度3.9 m/s,物料流量15 mL/min,得到产品包埋率和装载量分别是69.1%和10.6%。红外光谱结果表明,香兰素与β-环糊精存在分子间相互作用。热重-差热分析结果表明,微胶囊的形成提高了香兰素的热稳定性。粒度分析显示,在50 d存放期间,β-环糊精的平均粒径变化值为0.14~1.2μm,而产品的平均粒径变化值为0.011~0.22μm,后者比前者小,进一步印证了香兰素与β-环糊精形成了超分子微胶囊。
The preparation ofβ-cyclodextrin/vanillin microcapsules through spray-drying method has been investigated by the evaluation of loading efficiency and loading rate of the microcapsules. The optimal production conditions are as follows : p ( β-cyclodextrin ) = 79.5 g/L, n ( vanillin ) : n (β- cyclodextrin) = 0. 8:1.0, V( anhydrous ethanol) : V(water) = 1 : 10, inlet temperature 130 ℃, drying air speed 3.9 m/s, flow rate 15 mL/min. The loading efficiency and loading rate of the product were 69. 1% and 10.6% , respectively. FTIR spectra were used to demonstrate the intermolecular interaction between vanillin and fl-cyclodextrin. TG-DSC results confirmed that the thermal stability of vanillin was improved after being encapsulated by β-cyclodextrin. The particle size analysis suggests that the variation value of the average particle size of β-cyclodextrin was within the range of 0. 14 - 1.2 μm and that of the product was within the range of 0. 011 - 0.22 μm during 50 days' storage,the latter being much smaller than the former, which further verified the fabrication of supramolecular microcapsules.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2012年第7期678-682,共5页
Fine Chemicals
基金
海南省中药现代化专项(2011ZY005)
海口市重点科技计划项目(2011-0079)
国家自然科学基金(21036009)
2010年广东省高等学校高层次人才项目
中央高校基本科研业务费专项资金~~
关键词
香兰素
Β-环糊精
微胶囊
喷雾干燥
香料与香精
vanillin
β-cyclodextrin
microcapsules
spray-drying
perfumes and essences