规律体育锻炼干预老年轻度认知功能障碍的临床研究

Clinical research intervention of rule physical exercise on mild cognitive dysfunction in the elderl_y

目的观察规律体育锻炼对老年轻度认知功能障碍（MCI）患者的认知功能及生活质量影响。方法收集社区中有记忆减退主诉的老年人群，将诊断为退行性MCI（NMCI）及血管性MCI（VMCI）患者共163例纳入研究。各自按照有无体育锻炼意愿分为干预组和对照组，对干预组实施规律的体育锻炼督促、指导。应用神经心理学量表及生活质量评定表进行评估。结果两组病例的干预组干预前后比较：MMSE、AVMT5、ADL、SF-36、TMT、CFT、QUALITY的评分有统计学意义（渐进显著性〈0．01）。结论规律体育锻炼能有效改善MCI患者的认知功能及生活质量。

Objective To investigate the effect of physical exercise on the cognitive function and quality of life in the elderly patients with cognitive dysfunction （MCI）. Methods The elderly population with memory impairment Chief com- plaint in Huayang community were assessed via history taking, neuropsychological test collection and life quality evaluation, including simple mental state scale （MMSE）, clinical dementia rating scale （CDR）, hearing word memory scale （AVMT）, complex graphicsmemorytest （CFT1, CFT2）, attachment test （TMT1, TMT2）, speech fluencytest （VFT）, daily living skills scale （ADL）, touting the health survey （SF-36）, older depression scale （GDS）, life quality rating scale （QUAL）. According to the standard, 88 cases were included in the degenerative mild cognitive dysfunction （NMCI） patients and 75 cases of vascular mild cognitive dysfunction （VMCI） patients were studied. According to physical exercise, all cases were divided into intervention group treated with regular physical exercise supervision, and guidance and control group did not take any measures. Twice tests of neuropsychological and quality of life were repeated each six months. Results There were significant statistical differences in the scores of MMSE, AVMT5, ADL, SF-36, TMT, CFT and QUALITY before and after intervention in the two groups （P〈0.01）. Conclusion Rule physical exercise can effectively improve cognitive function and quality of life of patients with MCI.