高血压合并颈动脉粥样硬化患者动态血压特征分析

Characteristics of ambulatory blood pressure in hypertensive patients with carotid atherosclerosis

目的研究高血压合并颈动脉粥样硬化患者的动态血压特征和临床意义。方法选择高血压患者111例,行动态血压监测。所有患者行颈动脉超声检查,根据结果将患者分为斑块组66例和无斑块组45例,斑块组又根据斑块数量分为单一斑块组24例和多发斑块组42例。比较各组动态血压情况。结果斑块组较无斑块组患者24 h、昼间和夜间平均收缩压、舒张压和动脉压均显著增高(P<0.05),且斑块组非杓型血压发生率较无斑块组也显著增高(63.6%vs 44.4%,P<0.05);多发斑块组较单一斑块组患者24 h、昼间和夜间平均收缩压、舒张压和动脉压均显著增高(P<0.05),且多发斑块组非杓型血压发生率较单一斑块组显著增高(76.2%vs 41.7%,P<0.05)。结论持续血压升高是产生颈动脉粥样硬化的重要影响因素,且颈动脉斑块更易引发血压昼夜节律调节紊乱。

Objective To study the characteristics of ambulatory blood pressure（ABP） in hyperten- sive patients with carotid atherosclerosis and their clinical significance. Methods ABP was moni- tored in 111 hypertensive patients with carotid atherosclerosis. The patients were divided into plague group（n= 66） and non-plague group（n= 45）according to their carotid artery uhrason- graphic findings. The plague group was further divided into single plaque group（n= 24）and multi- ple plaque group（n=42）and their ABP was compared. Results The average 24 h,day and night SBP, DBP, and arterial pressure, non-spoon type blood pressure were significantly higher in plague group and muhiple plaque group than in non-plague group and single plague group （P〈0.05）. Conclusion Continuous blood pressure elevation is an important factor for the occurrence of ca- rotid atherosclerosis. Carotid artery plaque is easier to cause circadian rhythm disorders of blood pressure.