红细胞T_4浓度测定法及初步应用

RED BLOOD CELL THYROXINE IN HYPO-AND HYPER-THYROIDISM, NEPHROTIC SYNDROME AND NON-THYROID ILLNESS

本文介绍一种红细胞内T_4浓度测定方法。批内、批间变异系数各为5.64±0.47％和12.26±1.23％。RBC T_4正常值范围是1.2±0.1nmol/L,显著低于甲亢的4.4±0.8nmol/L和高于甲减的0.4±0.1nmol/L。分析结果表明RBC T_4和FT_4间有良好的相关性(r=0.908,P<0.001)。

Red blood cell T4 concentrations (RBC T4) were measured in 18 normal subjects, 35 patients with hypo- or hyper-thyroidism, 9 patients with non-thyroid illness, and 13 patients with nephrotic syndrome. The normal range for RBC T4 was 1.2 ±0.1 nmol/L. RBC T4 was below the normal range in all 14 patients with hypothyroidism and above the normal range in all 21 patients with hyperthyroidism and in 9 patients with severe non-thyroid illness sigmficantly. There was a significant linear correlation between RBC T4 and FT4 in all patients and normal subjects.