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多西紫杉醇联合贝伐单抗或安慰剂在HER2阴性转移性乳腺癌中的Ⅲ期临床研究 被引量:1

Phase Ⅲ Study of Bevacizumab plus Docetaxel Compared with Placebo plus Docetaxel for the First-Line Treatment of Human Epidermal Growth Factor Receptor 2-Negative Metastatic Breast Cancer
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摘要 3背景 ·E2100研究显示贝伐单抗联合每周紫杉醇相对安慰剂在转移性乳腺癌中能显著提高无进展生存期(11.4个月VS.5.8个月)。 ·多西紫杉醇是乳腺癌领域广泛使用的化疗药,临床前研究显示多西紫杉醇和贝伐单抗有协同作用。
出处 《循证医学》 CSCD 2012年第3期144-146,149,共4页 The Journal of Evidence-Based Medicine
关键词 乳腺癌 贝伐单抗 化疗 breast cancer Bevacizumab chemotherapy
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  • 1Miller K, Wang M, Gralow J, et al. Paclitaxel plus Bevacizumab versus Paclitaxel alone for metastatic breast caneer[J]. N Engl J Med, 2007,357(26):2666-2676.
  • 2Miles DW, Chan A, Dirix LY, et al. Phase Ⅲ study of Bevacizumab plus Docetaxel compared with placebo plus Docetaxel for the first-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer[J]. J Clin Oneol, 2010,28 (20) : 3239-3247.
  • 3Robert NJ, Dieras V, Glaspy J, et al. RIBBON-1 : Randomized, double-blind, placebo-controBed, phase Ⅲ trial of chemotherapy with or without Bevacizumab for first-line treatment of human epidermal growth factor receptor 2- negative, locally recurrent or metastatic breast cancer [J]. J Clin Oncol, 2011,29(10) : 1252-1260.
  • 4O'Shaughnessy JA, Brufsky AM. RIBBON 1 and RIBBON 2: phase Ⅲ trims of Bevacizumab with standard chemotherapy for metastatic breast cancer [J]. Clin Breast Cancer, 2008,8(4): 370-373.
  • 5Brufsky AM, Hurvitz S, Perez E, et al. RIBBON-2: A randomized, double-blind, placebo-controlled, phase Ⅲ trial evaluating the efficacy and safety of Bevacizumab in combination with chemotherapy for second-line treatment of human epidermal growth factor receptor 2-negative metastatic breast cancer [Jl. J Clin Oneol, 2011,29(32) :4286-4293.
  • 6von Minckwitz G, Eidtmann H, Rezai M, et al. Neoadjuvant chemotherapy and Bevacizumab for HER2-negative breast cancer[J]. N Engl J Med, 2012,566(4):299-309.

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