中药对环氧合酶-2的作用研究

Research of the effects of traditonal Chinese medicine on cyclooxygenase-2

花生四烯酸在环氧合酶(COX)的作用下产生前列腺素,前列腺素是产生炎症反应的主要介质。而环氧合酶-2是分解花生四烯酸生成各种内源性前列腺素过程中重要的限速酶。大量研究表明许多中药可通过对环氧合酶-2的抑制来发挥抗炎作用。现就近年在细胞水平及不同疾病中中药对环氧合酶-2作用的相关研究进行综述。

Arachidonic acid produces prostaglandins by the action of cyclooxygenase and prostaglandins is the main medium of an inflammatory response.Cyclooxygenase-2（COX-2） is an important rate-limiting enzyme in the process of the decomposition of arachidonic acid to generate a variety of endogenous prostaglandins.A large number of studies have shown that many herbs can play the anti-inflammatory effect through their inhibition of the action of COX-2.In this article recent research of traditional Chinese medicine on COX-2 in various diseases at the cellular level were reviewed.