非肥胖非胰岛素依赖型糖尿病红细胞胰岛素受体与血脂血电解质的关系

THE RELATIONSHIPS BETWEEN THE ERYTHROCYTE INSULIN RECEPTOR AND BLOOD LIPIDS AND ELECTROLYTES IN NON-OBESE NIDDM

非肥胖NIDDM病人红细胞胰岛素受体的4个参数Q_1、K_1、Q_2、K_2与血浆脂类、离子及微量元素的关系为:1.高亲和力胰岛素受体结合位点数目(Q_1)在血浆HDL_2或血镁水平高时可能增多;而在血锶水平高时可能减少。2.高亲和力胰岛素受体亲和常数(K_1)在血钙水平高时可能降低;血铜高时有降低趋势。3.低亲和力胰岛素受体结合位点数目(Q_2)在血锶水平高时可能减少;血铝水平高时可能增多。4.低亲和力胰岛素受体亲和常数(K_2)在血总胆固醇水平高时可能升高;而在血铝水平高时可能下降。提示这些微量元素对NIDDM病人的红细胞胰岛素受体结合可能均有抑制作用。

The correlations between the erythrocyte insulin receptor (EIR), 7 plasma lipids and 7 electrolytes including 4 trace elements were analyzed respectively with stepwise regression method using IBM-PC/XT computer. It was found that 1) The number of binding sites of the high affinity EIR (Q1) is positively correlated with plasma HDL, and Mg levels and negatively with that of Sr; 2) The affinity constant of high affinity EIR (K1) is negatively correlated with plasma Ca level and tends to decrease when plasma Cu increases; 3) The number of binding sites of the low affinity EIR (Q2) is negatively correlated with plasma Sr and positively with plasma Al; 4) The affinity constant of the low affinity EIR (K2) is positively correlated with plasma total cholesterol and negatively with plasma Al levels. In conclusion, high plasma Sr tends to reduce the Q1 and Q2 and high plasma Cu tends to decrease K1; although high plasma Al may increase Q2, it might be a compensatory response to the decreased K, at the level of receptor binding sites. These results suggest that all these trace elements Sr, Cu and Al might have an inhibitory effect on the binding of EIR in non-obese NIDDM.